Optical mapping and its potential for large-scale sequencing projects

Christopher Aston, Bud Mishra, David C. Schwartz

Research output: Contribution to journalReview articlepeer-review


Physical mapping has been rediscovered as an important component of large-scale sequencing projects. Restriction maps provide landmark sequences at defined intervals, and high-resolution restriction maps can be assembled from ensembles of single molecules by optical means. Such optical maps can be constructed from both large-insert clones and genomic DNA, and are used as a scaffold for accurately aligning sequence contigs generated by shotgun sequencing. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalTrends in Biotechnology
Issue number7
StatePublished - Jul 1 1999

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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