Optical mapping and its potential for large-scale sequencing projects

Christopher Aston; Bud Mishra; David C. Schwartz

doi:10.1016/S0167-7799(99)01326-8

Optical mapping and its potential for large-scale sequencing projects

Christopher Aston, Bud Mishra, David C. Schwartz

Computer Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Physical mapping has been rediscovered as an important component of large-scale sequencing projects. Restriction maps provide landmark sequences at defined intervals, and high-resolution restriction maps can be assembled from ensembles of single molecules by optical means. Such optical maps can be constructed from both large-insert clones and genomic DNA, and are used as a scaffold for accurately aligning sequence contigs generated by shotgun sequencing. Copyright (C) 1999 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	297-302
Number of pages	6
Journal	Trends in Biotechnology
Volume	17
Issue number	7
DOIs	https://doi.org/10.1016/S0167-7799(99)01326-8
State	Published - Jul 1 1999

ASJC Scopus subject areas

Biotechnology
Bioengineering

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10.1016/S0167-7799(99)01326-8

Cite this

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title = "Optical mapping and its potential for large-scale sequencing projects",

abstract = "Physical mapping has been rediscovered as an important component of large-scale sequencing projects. Restriction maps provide landmark sequences at defined intervals, and high-resolution restriction maps can be assembled from ensembles of single molecules by optical means. Such optical maps can be constructed from both large-insert clones and genomic DNA, and are used as a scaffold for accurately aligning sequence contigs generated by shotgun sequencing. Copyright (C) 1999 Elsevier Science Ltd.",

author = "Christopher Aston and Bud Mishra and Schwartz, {David C.}",

note = "Funding Information: The authors{\textquoteright} work was supported in part by grants from the US National Institutes of Health (HG-00225-08), the US Department of Energy and the Burroughs Wellcome Fund. ",

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AU - Mishra, Bud

AU - Schwartz, David C.

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Y1 - 1999/7/1

N2 - Physical mapping has been rediscovered as an important component of large-scale sequencing projects. Restriction maps provide landmark sequences at defined intervals, and high-resolution restriction maps can be assembled from ensembles of single molecules by optical means. Such optical maps can be constructed from both large-insert clones and genomic DNA, and are used as a scaffold for accurately aligning sequence contigs generated by shotgun sequencing. Copyright (C) 1999 Elsevier Science Ltd.

AB - Physical mapping has been rediscovered as an important component of large-scale sequencing projects. Restriction maps provide landmark sequences at defined intervals, and high-resolution restriction maps can be assembled from ensembles of single molecules by optical means. Such optical maps can be constructed from both large-insert clones and genomic DNA, and are used as a scaffold for accurately aligning sequence contigs generated by shotgun sequencing. Copyright (C) 1999 Elsevier Science Ltd.

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JO - Trends in Biotechnology

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Optical mapping and its potential for large-scale sequencing projects

Abstract

ASJC Scopus subject areas

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