Optical monitoring of rheumatoid arthritis: Monte Carlo generated reconstruction kernels

O. Minet, J. Beuthan, A. H. Hielscher, U. Zabarylo

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Optical imaging in biomedicine is governed by the light absorption and scattering interaction on microscopic and macroscopic constituents in the medium. Therefore, light scattering characteristics of human tissue correlate with the stage of some diseases. In the near infrared range the scattering event with the coefficient approximately two orders of magnitude greater than absorption plays a dominant role. When measuring the optical parameters variations were discovered that correlate with the rheumatoid arthritis of a small joint. The potential of an experimental setup for transillumination the finger joint with a laser diode and the pattern of the stray light detection are demonstrated. The scattering caused by skin contains no useful information and it can be removed by a deconvolution technique to enhance the diagnostic value of this non-invasive optical method. Monte Carlo simulations ensure both the construction of the corresponding point spread function and both the theoretical verification of the stray light picture in rather complex geometry.

    Original languageEnglish (US)
    Title of host publicationSaratov Fall Meeting 2007
    Subtitle of host publicationOptical Technologies in Biophysics and Medicine IX
    DOIs
    StatePublished - 2008
    EventSaratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX - Saratov, Russian Federation
    Duration: Sep 25 2007Sep 28 2007

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume6791
    ISSN (Print)1605-7422

    Conference

    ConferenceSaratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX
    CountryRussian Federation
    CitySaratov
    Period9/25/079/28/07

    Keywords

    • Deconvolution technique
    • Finger joint
    • Light scattering
    • Optical imaging

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

    Fingerprint Dive into the research topics of 'Optical monitoring of rheumatoid arthritis: Monte Carlo generated reconstruction kernels'. Together they form a unique fingerprint.

    Cite this