Optical tomographic and magnetic resonance imaging of tumor growth and regression in mice treated with VEGF blockade

J. Masciotti, G. Abdoulaev, F. Provenzano, J. Hur, J. Papa, J. Bae, J. Huang, D. Yamashiro, J. Kandel, A. H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Small animal imaging systems now allow researchers to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. Magnetic resonance imaging (MRI) is an established imaging modality capable of obtaining high resolution anatomical images which are sensitive to blood volume, blood flow, and metabolic rate of oxygen. Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution and insensitive to blood flow, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and blood volume with high temporal resolution. We illustrate how these imaging modalities can supplement each other and cross validation can be performed by applying both modalities to imaging of tumors growth & regression in mice that are treated with a vascular endothelial growth factor (VEGF) antagonist.

    Original languageEnglish (US)
    Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Pages205-208
    Number of pages4
    ISBN (Print)0780387406, 9780780387409
    DOIs
    StatePublished - 2005
    Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
    Duration: Sep 1 2005Sep 4 2005

    Publication series

    NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
    Volume7 VOLS
    ISSN (Print)0589-1019

    Conference

    Conference2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
    CountryChina
    CityShanghai
    Period9/1/059/4/05

    ASJC Scopus subject areas

    • Signal Processing
    • Biomedical Engineering
    • Computer Vision and Pattern Recognition
    • Health Informatics

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