TY - JOUR
T1 - Optical tomographic imaging of small animals
AU - Hielscher, Andreas H.
N1 - Funding Information:
I would like to thank Alexander Klose and Kui Ren from Columbia University for their helpful comments concerning transport-theory-based fluorescence tomography and frequency-domain transport theory. This work was supported in part by the National Institutes of Health (grant # R01 AR46255-02, National Institute of Arthritis and Musculoskeletal and Skin Diseases; grant # EB001900-01, National Institute of Biomedical Imaging and Bioengineering; grant # 5R33-CA91807, National Cancer Institute).
PY - 2005/2
Y1 - 2005/2
N2 - Diffuse optical tomography is emerging as a viable new biomedical imaging modality. Using visible and near-infrared light this technique can probe the absorption and scattering properties of biological tissues. The main applications are currently in brain, breast, limb and joint imaging; however, optical tomographic imaging of small animals is attracting increasing attention. This interest is fuelled by recent advances in the transgenic manipulation of small animals that has led to many models of human disease. In addition, an ever increasing number of optically reactive biochemical markers has become available, which allow diseases to be detected at the molecular level long before macroscopic symptoms appear. The past three years have seen an array of novel technological developments that have led to the first optical tomographic studies of small animals in the areas of cerebral ischemia and cancer.
AB - Diffuse optical tomography is emerging as a viable new biomedical imaging modality. Using visible and near-infrared light this technique can probe the absorption and scattering properties of biological tissues. The main applications are currently in brain, breast, limb and joint imaging; however, optical tomographic imaging of small animals is attracting increasing attention. This interest is fuelled by recent advances in the transgenic manipulation of small animals that has led to many models of human disease. In addition, an ever increasing number of optically reactive biochemical markers has become available, which allow diseases to be detected at the molecular level long before macroscopic symptoms appear. The past three years have seen an array of novel technological developments that have led to the first optical tomographic studies of small animals in the areas of cerebral ischemia and cancer.
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U2 - 10.1016/j.copbio.2005.01.002
DO - 10.1016/j.copbio.2005.01.002
M3 - Article
C2 - 15722019
AN - SCOPUS:13844256228
SN - 0958-1669
VL - 16
SP - 79
EP - 88
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
IS - 1 SPEC. ISS.
ER -