Optical tomographic imaging of vascular and metabolic reactivity in rheumatoid joints

Joseph M. Lasker, Edward Dwyer, Andreas H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Our group has recently established that joints affected by Rheumatoid Arthritis (RA) can be distinguished from healthy joints through measurements of the scattering coefficient. We showed that a high scattering coefficient in the center of the joint is indicative of a joint with RA. While these results were encouraging, data to date still suffers from low sensitivity and specificity. Possibly higher specificities and sensitivities can be achieved if dynamic measurements of hemodynamic and metabolic processes in the synovium are considered. Using our dual-wavelength imaging system together with previously implemented model-based iterative image reconstruction schemes, we have performed initial dynamic imaging studies involving healthy human volunteers and patients affected by RA. These case studies seem to confirm our hypothesis that differences in the vascular reactivity exist between affected and unaffected joints.

Original languageEnglish (US)
Title of host publicationOptical Tomography and Spectroscopy of Tissue VI
Subtitle of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Pages406-416
Number of pages11
Volume5693
DOIs
StatePublished - 2005
EventOptical Tomography and Spectroscopy of Tissue VI - San Jose, CA, United States
Duration: Jan 23 2005Jan 26 2005

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
ISSN (Print)1605-7422

Conference

ConferenceOptical Tomography and Spectroscopy of Tissue VI
Country/TerritoryUnited States
CitySan Jose, CA
Period1/23/051/26/05

Keywords

  • Dynamics
  • Imaging
  • Optical tomography
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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