Optimal control NMR differentiation between fast and slow sodium

Jae Seung Lee; Ravinder R. Regatte; Alexej Jerschow

doi:10.1016/j.cplett.2010.06.019

Optimal control NMR differentiation between fast and slow sodium

Jae Seung Lee, Ravinder R. Regatte, Alexej Jerschow

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Sodium ions in tissues and organs may experience motion on a variety of timescales, leading to NMR relaxation effects with quadrupolar coupling as the primary mechanism. The various effects that this fluctuating interaction has on spin dynamics can be exploited for distinguishing slow sodium ions from fast ones. Techniques such as triple-quantum filtering have been used for this purpose in the past. In this work we present optimal pulses which significantly improve the selectivity towards slow-tumbling sodium. These pulses can also be modified for robustness against magnetic field inhomogeneities, and could hence also become useful as MRI contrast methods.

Original language	English (US)
Pages (from-to)	331-336
Number of pages	6
Journal	Chemical Physics Letters
Volume	494
Issue number	4-6
DOIs	https://doi.org/10.1016/j.cplett.2010.06.019
State	Published - Jul 19 2010

ASJC Scopus subject areas

Physics and Astronomy(all)
Physical and Theoretical Chemistry

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10.1016/j.cplett.2010.06.019

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title = "Optimal control NMR differentiation between fast and slow sodium",

abstract = "Sodium ions in tissues and organs may experience motion on a variety of timescales, leading to NMR relaxation effects with quadrupolar coupling as the primary mechanism. The various effects that this fluctuating interaction has on spin dynamics can be exploited for distinguishing slow sodium ions from fast ones. Techniques such as triple-quantum filtering have been used for this purpose in the past. In this work we present optimal pulses which significantly improve the selectivity towards slow-tumbling sodium. These pulses can also be modified for robustness against magnetic field inhomogeneities, and could hence also become useful as MRI contrast methods.",

author = "Lee, {Jae Seung} and Regatte, {Ravinder R.} and Alexej Jerschow",

note = "Funding Information: We acknowledge funding from the US National Science Foundation under Grant No. CHE0554400 , and from the National Institutes of Health under Grant No. 5R21AR055724-02 . This research was further supported in part by the National Science Foundation under Grant No. PHY05-51164 (Quantum Control Workshop at the Kavli Institute for Theoretical Physics).",

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doi = "10.1016/j.cplett.2010.06.019",

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AU - Lee, Jae Seung

AU - Regatte, Ravinder R.

AU - Jerschow, Alexej

N1 - Funding Information: We acknowledge funding from the US National Science Foundation under Grant No. CHE0554400 , and from the National Institutes of Health under Grant No. 5R21AR055724-02 . This research was further supported in part by the National Science Foundation under Grant No. PHY05-51164 (Quantum Control Workshop at the Kavli Institute for Theoretical Physics).

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Y1 - 2010/7/19

N2 - Sodium ions in tissues and organs may experience motion on a variety of timescales, leading to NMR relaxation effects with quadrupolar coupling as the primary mechanism. The various effects that this fluctuating interaction has on spin dynamics can be exploited for distinguishing slow sodium ions from fast ones. Techniques such as triple-quantum filtering have been used for this purpose in the past. In this work we present optimal pulses which significantly improve the selectivity towards slow-tumbling sodium. These pulses can also be modified for robustness against magnetic field inhomogeneities, and could hence also become useful as MRI contrast methods.

AB - Sodium ions in tissues and organs may experience motion on a variety of timescales, leading to NMR relaxation effects with quadrupolar coupling as the primary mechanism. The various effects that this fluctuating interaction has on spin dynamics can be exploited for distinguishing slow sodium ions from fast ones. Techniques such as triple-quantum filtering have been used for this purpose in the past. In this work we present optimal pulses which significantly improve the selectivity towards slow-tumbling sodium. These pulses can also be modified for robustness against magnetic field inhomogeneities, and could hence also become useful as MRI contrast methods.

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Optimal control NMR differentiation between fast and slow sodium

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