Optimal data-driven sparse parameterization of diffeomorphisms for population analysis

Sandy Durrleman, Marcel Prastawa, Guido Gerig, Sarang Joshi

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    In this paper, we propose a novel approach for intensity based atlas construction from a population of anatomical images, that estimates not only a template representative image but also a common optimal parameterization of the anatomical variations evident in the population. First, we introduce a discrete parameterization of large diffeomorphic deformations based on a finite set of control points, so that deformations are characterized by a low dimensional geometric descriptor. Second, we optimally estimate the position of the control points in the template image domain. As a consequence, control points move to where they are needed most to capture the geometric variability evident in the population. Third, the optimal number of control points is estimated by using a log - L1 sparsity penalty. The estimation of the template image, the template-to-subject mappings and their optimal parameterization is done via a single gradient descent optimization, and at the same computational cost as independent template-to-subject registrations. We present results that show that the anatomical variability of the population can be encoded efficiently with these compact and adapted geometric descriptors.

    Original languageEnglish (US)
    Title of host publicationInformation Processing in Medical Imaging - 22nd International Conference, IPMI 2011, Proceedings
    PublisherSpringer Verlag
    Pages123-134
    Number of pages12
    ISBN (Print)9783642220913
    DOIs
    StatePublished - 2011
    Event22nd International Conference on Information Processing in Medical Imaging, IPMI 2011 - Kloster Irsee, Germany
    Duration: Jul 3 2011Jul 8 2011

    Publication series

    NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Volume6801 LNCS
    ISSN (Print)0302-9743
    ISSN (Electronic)1611-3349

    Other

    Other22nd International Conference on Information Processing in Medical Imaging, IPMI 2011
    CountryGermany
    CityKloster Irsee
    Period7/3/117/8/11

    ASJC Scopus subject areas

    • Theoretical Computer Science
    • Computer Science(all)

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