TY - JOUR
T1 - Optimization of Multicomponent Behavioral and Biobehavioral Interventions for the Prevention and Treatment of HIV/AIDS
AU - Collins, Linda M.
AU - Kugler, Kari C.
AU - Gwadz, Marya Viorst
N1 - Funding Information:
The word described herein was supported by Grant R03 HD079711 from the Eunice Kennedy Shriver Institute for Child Health and Human Development; grants P50 DA010075, R01 DA032083, and P30 DA011041 from the National Institute on Drug Abuse; grant R01 DK097364 from the National Institute for Diabetes and Digestive and Kidney Diseases; and grant P01 CA180945 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the institutes mentioned above.
Funding Information:
Funding from the US National Institutes of Health (NIH), as well as many funding agencies inside and outside the US, usually is provided for a maximum of 5 years. Depending on the endeavor it may be difficult to complete all three phases of MOST in a single 5-year study, even if much of the preparation phase is completed at the time of writing a grant proposal. Whether a 5-year plan of work can reasonably include the evaluation phase in addition to the optimization phase is largely dependent on two considerations. One is how rapidly research subjects can be recruited. In some domains, such as school-based research, large numbers of subjects can be recruited rapidly all at once; in other domains, such as many studies in medical settings, recruitment is on a rolling basis, meaning that it is dependent on the rate at which patients walk into a particular clinic or are admitted to a hospital.
Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - To move society toward an AIDS-free generation, behavioral interventions for prevention and treatment of HIV/AIDS must be not only effective, but also cost-effective, efficient, and readily scalable. The purpose of this article is to introduce to the HIV/AIDS research community the multiphase optimization strategy (MOST), a new methodological framework inspired by engineering principles and designed to develop behavioral interventions that have these important characteristics. Many behavioral interventions comprise multiple components. In MOST, randomized experimentation is conducted to assess the individual performance of each intervention component, and whether its presence/absence/setting has an impact on the performance of other components. This information is used to engineer an intervention that meets a specific optimization criterion, defined a priori in terms of effectiveness, cost, cost-effectiveness, and/or scalability. MOST will enable intervention science to develop a coherent knowledge base about what works and does not work. Ultimately this will improve behavioral interventions systematically and incrementally.
AB - To move society toward an AIDS-free generation, behavioral interventions for prevention and treatment of HIV/AIDS must be not only effective, but also cost-effective, efficient, and readily scalable. The purpose of this article is to introduce to the HIV/AIDS research community the multiphase optimization strategy (MOST), a new methodological framework inspired by engineering principles and designed to develop behavioral interventions that have these important characteristics. Many behavioral interventions comprise multiple components. In MOST, randomized experimentation is conducted to assess the individual performance of each intervention component, and whether its presence/absence/setting has an impact on the performance of other components. This information is used to engineer an intervention that meets a specific optimization criterion, defined a priori in terms of effectiveness, cost, cost-effectiveness, and/or scalability. MOST will enable intervention science to develop a coherent knowledge base about what works and does not work. Ultimately this will improve behavioral interventions systematically and incrementally.
KW - Behavioral intervention
KW - Biobehavioral intervention
KW - Factorial design
KW - Fractional factorial design
KW - Multiphase optimization strategy
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U2 - 10.1007/s10461-015-1145-4
DO - 10.1007/s10461-015-1145-4
M3 - Article
C2 - 26238037
AN - SCOPUS:84955189136
SN - 1090-7165
VL - 20
SP - 197
EP - 214
JO - AIDS and Behavior
JF - AIDS and Behavior
ER -