Oral bacterial decontamination using an innovative prototype for photocatalytic disinfection

Matheus Albino Souza, Daniela Jorge Corralo, Ezequiel Santin Gabrielli, José Antônio Poli Figueiredo, Stephen Cohen, Mark Wolff, Liviu Steier

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The aim of this study was to evaluate the effectiveness of a prototype photocatalytic device for bacterial decontaminations of the oral cavity. Methods: Sixty-four subjects (18–65) were selected and randomly assigned to eight groups (n = 8), according to oral disinfection protocol: (G1): distilled water (control); (G2): 1.5% hydrogen peroxide (HP); (G3): 3.0% HP; (G4): 0.12% chlorhexidine (CHX); (G5): Germinator; (G6): 1.5% HP + Germinator; (G7): 3.0%HP + Germinator; (G8): 0.12% CHX + Germinator. Stimulated saliva was collected before and after a 3-min mouthwash and/or Germinator application. The patients were kept relaxed and retained saliva 5–10 min, spitting out into the tube for 3 min. The percentage bacterial reduction was checked by counting the colony-forming units (CFUs) after culturing on blood agar plates. Data were subjected to one-way ANOVA followed by Tukey’s post hoc test (α = 5%) for statistical significance. Results: The highest bacterial reduction was observed in groups 3 (3.0% HP), 6 (1.5% HP + Germinator), and 7 (3.0% + Germinator), with no statistically significant difference between them (p > 0.05). Groups 6 (1.5% HP + Germinator) and 8 (0.12% CHX + Germinator) showed higher bacterial reduction than groups 2 (1.5% HP) and 4 (0.12% CHX) (p < 0.05). Finally, group 5 (Germinator) showed higher bacterial reduction than control group (DW) and group 4 (0.12% CHX) (p < 0.05). Conclusions: The photocatalytic disinfection was effective against oral bacteria and improved the antimicrobial action of 1.5% HP and 0.12%. Clinical significance. The photocatalytic disinfection can be an alternative protocol to provide the oral decontamination.

Original languageEnglish (US)
Pages (from-to)3005-3010
Number of pages6
JournalClinical Oral Investigations
Volume26
Issue number3
DOIs
StatePublished - Mar 2022

Keywords

  • Dental technology
  • Mouth rinse
  • Oral health
  • Humans
  • Middle Aged
  • Disinfection
  • Chlorhexidine/pharmacology
  • Young Adult
  • Decontamination
  • Adolescent
  • Adult
  • Bacteria
  • Mouth/microbiology
  • Aged

ASJC Scopus subject areas

  • Dentistry(all)

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