Oral Cancer: Genetics and the Role of Precision Medicine

Chia Cheng Li; Zhen Shen; Roxanne Bavarian; Fan Yang; Aditi Bhattacharya

doi:10.1016/j.cden.2017.08.002

Oral Cancer: Genetics and the Role of Precision Medicine

Chia Cheng Li, Zhen Shen, Roxanne Bavarian, Fan Yang, Aditi Bhattacharya

Oral and Maxillofacial Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world. OSCC patients are managed with surgery and/or chemoradiation. Prognoses and survival rates are dismal, however, and have not improved for more than 20 years. Recently, the concept of precision medicine was introduced, and the introduction of targeted therapeutics demonstrated promising outcomes. This article reviews the current understanding of initiation, progression, and metastasis of OSCC from both genetic and epigenetic perspectives. In addition, the applications and integration of omics technologies in biomarker discovery and drug development for treating OSCC are reviewed.

Original language	English (US)
Pages (from-to)	29-46
Number of pages	18
Journal	Dental clinics of North America
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/j.cden.2017.08.002
State	Published - Jan 2018

Keywords

Big data
Epigenetics
Malignant transformation
Omics technology
Oral cancer
Oral squamous cell carcinoma
Personalized medicine
Precision medicine

ASJC Scopus subject areas

General Dentistry

Access to Document

10.1016/j.cden.2017.08.002

Cite this

@article{a566aeaa4cfa4fed86d447d079d1657c,

title = "Oral Cancer: Genetics and the Role of Precision Medicine",

abstract = "Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world. OSCC patients are managed with surgery and/or chemoradiation. Prognoses and survival rates are dismal, however, and have not improved for more than 20 years. Recently, the concept of precision medicine was introduced, and the introduction of targeted therapeutics demonstrated promising outcomes. This article reviews the current understanding of initiation, progression, and metastasis of OSCC from both genetic and epigenetic perspectives. In addition, the applications and integration of omics technologies in biomarker discovery and drug development for treating OSCC are reviewed.",

keywords = "Big data, Epigenetics, Malignant transformation, Omics technology, Oral cancer, Oral squamous cell carcinoma, Personalized medicine, Precision medicine",

author = "Li, {Chia Cheng} and Zhen Shen and Roxanne Bavarian and Fan Yang and Aditi Bhattacharya",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2018",

month = jan,

doi = "10.1016/j.cden.2017.08.002",

language = "English (US)",

volume = "62",

pages = "29--46",

journal = "Dental clinics of North America",

issn = "0011-8532",

publisher = "W.B. Saunders Ltd",

number = "1",

}

TY - JOUR

T1 - Oral Cancer

T2 - Genetics and the Role of Precision Medicine

AU - Li, Chia Cheng

AU - Shen, Zhen

AU - Bavarian, Roxanne

AU - Yang, Fan

AU - Bhattacharya, Aditi

PY - 2018/1

Y1 - 2018/1

N2 - Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world. OSCC patients are managed with surgery and/or chemoradiation. Prognoses and survival rates are dismal, however, and have not improved for more than 20 years. Recently, the concept of precision medicine was introduced, and the introduction of targeted therapeutics demonstrated promising outcomes. This article reviews the current understanding of initiation, progression, and metastasis of OSCC from both genetic and epigenetic perspectives. In addition, the applications and integration of omics technologies in biomarker discovery and drug development for treating OSCC are reviewed.

AB - Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world. OSCC patients are managed with surgery and/or chemoradiation. Prognoses and survival rates are dismal, however, and have not improved for more than 20 years. Recently, the concept of precision medicine was introduced, and the introduction of targeted therapeutics demonstrated promising outcomes. This article reviews the current understanding of initiation, progression, and metastasis of OSCC from both genetic and epigenetic perspectives. In addition, the applications and integration of omics technologies in biomarker discovery and drug development for treating OSCC are reviewed.

KW - Big data

KW - Epigenetics

KW - Malignant transformation

KW - Omics technology

KW - Oral cancer

KW - Oral squamous cell carcinoma

KW - Personalized medicine

KW - Precision medicine

UR - http://www.scopus.com/inward/record.url?scp=85034254455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034254455&partnerID=8YFLogxK

U2 - 10.1016/j.cden.2017.08.002

DO - 10.1016/j.cden.2017.08.002

M3 - Review article

C2 - 29126492

AN - SCOPUS:85034254455

SN - 0011-8532

VL - 62

SP - 29

EP - 46

JO - Dental clinics of North America

JF - Dental clinics of North America

IS - 1

ER -

Oral Cancer: Genetics and the Role of Precision Medicine

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this