Oral Cancer: Genetics and the Role of Precision Medicine

Chia Cheng Li, Zhen Shen, Roxanne Bavarian, Fan Yang, Aditi Bhattacharya

Research output: Contribution to journalReview article

Abstract

Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world. OSCC patients are managed with surgery and/or chemoradiation. Prognoses and survival rates are dismal, however, and have not improved for more than 20 years. Recently, the concept of precision medicine was introduced, and the introduction of targeted therapeutics demonstrated promising outcomes. This article reviews the current understanding of initiation, progression, and metastasis of OSCC from both genetic and epigenetic perspectives. In addition, the applications and integration of omics technologies in biomarker discovery and drug development for treating OSCC are reviewed.

Original languageEnglish (US)
Pages (from-to)127-144
Number of pages18
JournalSurgical Oncology Clinics of North America
Volume29
Issue number1
DOIs
StatePublished - Jan 2020

Keywords

  • Big data
  • Epigenetics
  • Malignant transformation
  • Omics technology
  • Oral cancer
  • Oral squamous cell carcinoma
  • Personalized medicine
  • Precision medicine

ASJC Scopus subject areas

  • Surgery
  • Oncology

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