TY - JOUR
T1 - Oral complications in children with cancer
AU - Childers, Noel K.
AU - Stinnett, Elizabeth A.
AU - Wheeler, Pamela
AU - Wright, J. Timothy
AU - Castleberry, Robert P.
AU - Dasanayake, Ananda P.
N1 - Funding Information:
Supported by U.S.P.H.S. grants from the National Institute of Dental Research (DE-00155 and DE-08888). aAssistant Professor, Department of Community and Public Health Dentistry, University of Alabama at Birmingham. bPrivate practice of pediatric dentistry, Dothan, Ala. CThe Children’s Hospital of Alabama. dAssociate Professor, Department of Pediatric Dentistry, University of North Carolina School of Dentistry. eProfessoro f Pediatrics, University of Alabama at Birmingham. ‘Department of Epidemiology, School of Public Health, University of Alabama at Birmingham.
PY - 1993/1
Y1 - 1993/1
N2 - Oral complications during cancer therapy are a common source of discomfort and a potential source of systemic infection. We report the results of a 2 1 2-year prospective follow-up study on the incidence of oral complications in 214 pediatric patients with cancer. Overall, the incidence of ulcers in these patients ranked highest followed by gingivitis. Children with sarcomas had more ulcers (p = 0.03) and Candida infections (p = 0.03) than those with leukemia. The rate of gingivitis among patients with leukemia was five times higher than in patients with sarcoma (p = 0.02). Candida infections in children with solid tumors occurred four times more often than in patients with leukemia (p = 0.02). This study shows that oral complications are a frequent cause of morbidity in children with cancers and are more common in some cancers than in others. Oral complications may be prevented or diminished in severity by identifying the risk groups and developing preventive and treatment strategies.
AB - Oral complications during cancer therapy are a common source of discomfort and a potential source of systemic infection. We report the results of a 2 1 2-year prospective follow-up study on the incidence of oral complications in 214 pediatric patients with cancer. Overall, the incidence of ulcers in these patients ranked highest followed by gingivitis. Children with sarcomas had more ulcers (p = 0.03) and Candida infections (p = 0.03) than those with leukemia. The rate of gingivitis among patients with leukemia was five times higher than in patients with sarcoma (p = 0.02). Candida infections in children with solid tumors occurred four times more often than in patients with leukemia (p = 0.02). This study shows that oral complications are a frequent cause of morbidity in children with cancers and are more common in some cancers than in others. Oral complications may be prevented or diminished in severity by identifying the risk groups and developing preventive and treatment strategies.
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U2 - 10.1016/0030-4220(93)90404-R
DO - 10.1016/0030-4220(93)90404-R
M3 - Article
C2 - 8419873
AN - SCOPUS:0027405210
SN - 0030-4220
VL - 75
SP - 41
EP - 47
JO - Oral Surgery, Oral Medicine, Oral Pathology
JF - Oral Surgery, Oral Medicine, Oral Pathology
IS - 1
ER -