Orienting an Organic Semiconductor into DNA 3D Arrays by Covalent Bonds

Xiao Wang, Rahul Deshmukh, Ruojie Sha, Jens J. Birktoft, Vinod Menon, Nadrian C. Seeman, James W. Canary

Research output: Contribution to journalArticlepeer-review


A quasi-one-dimensional organic semiconductor, hepta(p-phenylene vinylene) (HPV), was incorporated into a DNA tensegrity triangle motif using a covalent strategy. 3D arrays were self-assembled from an HPV-DNA pseudo-rhombohedron edge by rational design and characterized by X-ray diffraction. Templated by the DNA motif, HPV molecules exist as single-molecule fluorescence emitters at the concentration of 8 mM within the crystal lattice. The anisotropic fluorescence emission from HPV-DNA crystals indicates HPV molecules are well aligned in the macroscopic 3D DNA lattices. Sophisticated nanodevices and functional materials constructed from DNA can be developed from this strategy by addressing functional components with molecular accuracy.

Original languageEnglish (US)
Article numbere202115155
JournalAngewandte Chemie - International Edition
Issue number5
StatePublished - Jan 26 2022

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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