Nicola C. Partridge, Carole Le Henaff

Research output: Chapter in Book/Report/Conference proceedingChapter


Bone is a dynamic tissue which is constantly renewed by a precise balance between osteoblastic bone formation and osteoclastic bone resorption. This process is important for normal bone mass and strength, and for mineral homeostasis. Bone remodeling is stringently regulated by communication between bone cells such as osteoclasts, osteoblasts and osteocytes and by systemic factors. An imbalance can result in bone diseases including osteoporosis. Resorption by osteoclasts precedes bone formation by osteoblasts. The osteocytes, within the bone matrix, contribute to the control of bone remodeling. In this article, we present the current knowledge of the structure, characteristics and functions of bone cells.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Cell Biology
Subtitle of host publicationVolume 1-6, Second Edition
Number of pages9
ISBN (Electronic)9780128216248
StatePublished - Jan 1 2022


  • Bone formation
  • Bone resorption
  • Bone-specific transcription factors
  • Collagen
  • Haematopoietic transcription factors
  • Mineralized bone
  • Osteoblast differentiation
  • Osteoblasts
  • Osteocalcin
  • Osteoclastogenesis
  • Osteoclasts
  • Osteocytes
  • Osteoid
  • Osteomorphs
  • Sclerostin

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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