Osteoclasts/Osteoblasts

Nicola C. Partridge; Carole Le Henaff

doi:10.1016/B978-0-12-821618-7.00139-5

Osteoclasts/Osteoblasts

Nicola C. Partridge, Carole Le Henaff

Molecular Pathobiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Bone is a dynamic tissue which is constantly renewed by a precise balance between osteoblastic bone formation and osteoclastic bone resorption. This process is important for normal bone mass and strength, and for mineral homeostasis. Bone remodeling is stringently regulated by communication between bone cells such as osteoclasts, osteoblasts and osteocytes and by systemic factors. An imbalance can result in bone diseases including osteoporosis. Resorption by osteoclasts precedes bone formation by osteoblasts. The osteocytes, within the bone matrix, contribute to the control of bone remodeling. In this article, we present the current knowledge of the structure, characteristics and functions of bone cells.

Original language	English (US)
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Volume 1-6, Second Edition
Publisher	Elsevier
Pages	30-38
Number of pages	9
Volume	6
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00139-5
State	Published - Jan 1 2022

Keywords

Bone formation
Bone resorption
Bone-specific transcription factors
Collagen
Haematopoietic transcription factors
Mineralized bone
Osteoblast differentiation
Osteoblasts
Osteocalcin
Osteoclastogenesis
Osteoclasts
Osteocytes
Osteoid
Osteomorphs
Sclerostin

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-821618-7.00139-5

Cite this

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abstract = "Bone is a dynamic tissue which is constantly renewed by a precise balance between osteoblastic bone formation and osteoclastic bone resorption. This process is important for normal bone mass and strength, and for mineral homeostasis. Bone remodeling is stringently regulated by communication between bone cells such as osteoclasts, osteoblasts and osteocytes and by systemic factors. An imbalance can result in bone diseases including osteoporosis. Resorption by osteoclasts precedes bone formation by osteoblasts. The osteocytes, within the bone matrix, contribute to the control of bone remodeling. In this article, we present the current knowledge of the structure, characteristics and functions of bone cells.",

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AB - Bone is a dynamic tissue which is constantly renewed by a precise balance between osteoblastic bone formation and osteoclastic bone resorption. This process is important for normal bone mass and strength, and for mineral homeostasis. Bone remodeling is stringently regulated by communication between bone cells such as osteoclasts, osteoblasts and osteocytes and by systemic factors. An imbalance can result in bone diseases including osteoporosis. Resorption by osteoclasts precedes bone formation by osteoblasts. The osteocytes, within the bone matrix, contribute to the control of bone remodeling. In this article, we present the current knowledge of the structure, characteristics and functions of bone cells.

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KW - Bone resorption

KW - Bone-specific transcription factors

KW - Collagen

KW - Haematopoietic transcription factors

KW - Mineralized bone

KW - Osteoblast differentiation

KW - Osteoblasts

KW - Osteocalcin

KW - Osteoclastogenesis

KW - Osteoclasts

KW - Osteocytes

KW - Osteoid

KW - Osteomorphs

KW - Sclerostin

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BT - Encyclopedia of Cell Biology

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Osteoclasts/Osteoblasts

Abstract

Keywords

ASJC Scopus subject areas

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