Overcoming transport barriers to immunotherapy

Shann S. Yu; Jeffrey A. Hubbell; Melody A. Swartz

doi:10.1007/s13346-021-01084-4

Overcoming transport barriers to immunotherapy

Shann S. Yu, Jeffrey A. Hubbell, Melody A. Swartz

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Immunotherapies are designed to treat disease by modulating the activity of immune cells. Here, we consider how anatomy and microphysiology create transport barriers to immunotherapeutic delivery and retention at diseased sites, and summarize recent developments to overcome these barriers by exploiting immunobiology to engineer molecular and cellular engineering approaches. Creating impactful and practical solutions across these diseases requires the integration of the collective expertise of pathologists, clinicians, immunologists, biophysicists, immunoengineers, and more.

Original language	English (US)
Pages (from-to)	2273-2275
Number of pages	3
Journal	Drug Delivery and Translational Research
Volume	11
Issue number	6
DOIs	https://doi.org/10.1007/s13346-021-01084-4
State	Published - Dec 2021

Keywords

Cellular engineering
Drug delivery
Immunoengineering
Immunotherapy
Molecular engineering
Pharmacodynamics
Pharmacokinetics

ASJC Scopus subject areas

Pharmaceutical Science

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10.1007/s13346-021-01084-4

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title = "Overcoming transport barriers to immunotherapy",

abstract = "Immunotherapies are designed to treat disease by modulating the activity of immune cells. Here, we consider how anatomy and microphysiology create transport barriers to immunotherapeutic delivery and retention at diseased sites, and summarize recent developments to overcome these barriers by exploiting immunobiology to engineer molecular and cellular engineering approaches. Creating impactful and practical solutions across these diseases requires the integration of the collective expertise of pathologists, clinicians, immunologists, biophysicists, immunoengineers, and more.",

keywords = "Cellular engineering, Drug delivery, Immunoengineering, Immunotherapy, Molecular engineering, Pharmacodynamics, Pharmacokinetics",

author = "Yu, {Shann S.} and Hubbell, {Jeffrey A.} and Swartz, {Melody A.}",

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doi = "10.1007/s13346-021-01084-4",

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AB - Immunotherapies are designed to treat disease by modulating the activity of immune cells. Here, we consider how anatomy and microphysiology create transport barriers to immunotherapeutic delivery and retention at diseased sites, and summarize recent developments to overcome these barriers by exploiting immunobiology to engineer molecular and cellular engineering approaches. Creating impactful and practical solutions across these diseases requires the integration of the collective expertise of pathologists, clinicians, immunologists, biophysicists, immunoengineers, and more.

KW - Cellular engineering

KW - Drug delivery

KW - Immunoengineering

KW - Immunotherapy

KW - Molecular engineering

KW - Pharmacodynamics

KW - Pharmacokinetics

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Overcoming transport barriers to immunotherapy

Abstract

Keywords

ASJC Scopus subject areas

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