Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: Insight from oxygen-18 labeling experiments

Conor Crean; Nicholas E. Geacintov; Vladimir Shafirovich

doi:10.1002/anie.200500991

Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: Insight from oxygen-18 labeling experiments

Conor Crean, Nicholas E. Geacintov, Vladimir Shafirovich

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(Figure Presented) Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by ¹⁸O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O^- from CO_3.- to the end products (see scheme).

Original language	English (US)
Pages (from-to)	5057-5060
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	32
DOIs	https://doi.org/10.1002/anie.200500991
State	Published - Aug 12 2005

Keywords

DNA damage
Isotopic labeling
Oxidation
Radical reactions
Reaction mechanisms

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200500991

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abstract = "(Figure Presented) Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by 18O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O- from CO3.- to the end products (see scheme).",

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author = "Conor Crean and Geacintov, {Nicholas E.} and Vladimir Shafirovich",

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AU - Shafirovich, Vladimir

PY - 2005/8/12

Y1 - 2005/8/12

N2 - (Figure Presented) Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by 18O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O- from CO3.- to the end products (see scheme).

AB - (Figure Presented) Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by 18O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O- from CO3.- to the end products (see scheme).

KW - DNA damage

KW - Isotopic labeling

KW - Oxidation

KW - Radical reactions

KW - Reaction mechanisms

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Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: Insight from oxygen-18 labeling experiments

Abstract

Keywords

ASJC Scopus subject areas

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