Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: Insight from oxygen-18 labeling experiments

Conor Crean, Nicholas E. Geacintov, Vladimir Shafirovich

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented) Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by 18O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O- from CO3.- to the end products (see scheme).

Original languageEnglish (US)
Pages (from-to)5057-5060
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number32
DOIs
StatePublished - Aug 12 2005

Keywords

  • DNA damage
  • Isotopic labeling
  • Oxidation
  • Radical reactions
  • Reaction mechanisms

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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