TY - GEN
T1 - Oxidation-responsive polymeric vesicles
AU - Napoli, A.
AU - Tirelli, N.
AU - Hubbell, J. A.
PY - 2004
Y1 - 2004
N2 - The role of a new class of oxidative-responsive polymeric vesicles that could be applied as nanocontainers in drug delivery, biosensing and biodetection was discussed. It was observed that the synthetic path was based on the anionic ring-opening polymerization of episulfides, initiated by a thiolate group. It was also found that the oxidation sensitivity of the vesicles were investigated by turbidimetry. Vesicle degradation was investigated when the oxidative environment was generated by the system glucose-oxidase (Gox)/glucose/O 2. A 1H nuclear magnetic resonance (NMR) spectroscopy of the polymersome suspensions was also employed before, during and after oxidation to characterize the nature of the observed morphological changes.
AB - The role of a new class of oxidative-responsive polymeric vesicles that could be applied as nanocontainers in drug delivery, biosensing and biodetection was discussed. It was observed that the synthetic path was based on the anionic ring-opening polymerization of episulfides, initiated by a thiolate group. It was also found that the oxidation sensitivity of the vesicles were investigated by turbidimetry. Vesicle degradation was investigated when the oxidative environment was generated by the system glucose-oxidase (Gox)/glucose/O 2. A 1H nuclear magnetic resonance (NMR) spectroscopy of the polymersome suspensions was also employed before, during and after oxidation to characterize the nature of the observed morphological changes.
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M3 - Conference contribution
AN - SCOPUS:13844272298
SN - 1877040193
SN - 9781877040191
T3 - Transactions - 7th World Biomaterials Congress
SP - 1054
BT - Transactions - 7th World Biomaterials Congress
T2 - Transactions - 7th World Biomaterials Congress
Y2 - 17 May 2004 through 21 May 2004
ER -