In this paper, we design the first polynomial time approximation schemes for the Set Cover and Dominating Set problems when the underlying sets are non-piercing regions (which include pseudodisks). We show that the local search algorithm that yields PTASs when the regions are disks [5, 19, 28] can be extended to work for non-piercing regions. While such an extension is intuitive and natural, attempts to settle this question have failed even for pseudodisks. The techniques used for analysis when the regions are disks rely heavily on the underlying geometry, and do not extend to topologically defined settings such as pseudodisks. In order to prove our results, we introduce novel techniques that we believe will find applications in other problems. We then consider the Capacitated Region Packing problem. Here, the input consists of a set of points with capacities, and a set of regions. The objective is to pick a maximum cardinality subset of regions so that no point is covered by more regions than its capacity. We show that this problem admits a PTAS when the regions are k-admissible regions (pseudodisks are 2-admissible), and the capacities are bounded. Our result settles a conjecture of Har-Peled (see Conclusion of ) in the affirmative. The conjecture was for a weaker version of the problem, namely when the regions are pseudodisks, the capacities are uniform, and the point set consists of all points in the plane. Finally, we consider the Capacitated Point Packing problem. In this setting, the regions have capacities, and our objective is to find a maximum cardinality subset of points such that no region has more points than its capacity. We show that this problem admits a PTAS when the capacity is unity, extending one of the results of Ene et al. .