Palladium-catalyzed amination reactions in flow: Overcoming the challenges of clogging via acoustic irradiation

Timothy Noêl; John R. Naber; Ryan L. Hartman; Jonathan P. McMullen; Klavs F. Jensen; Stephen L. Buchwald

doi:10.1039/c0sc00524j

Palladium-catalyzed amination reactions in flow: Overcoming the challenges of clogging via acoustic irradiation

Timothy Noêl, John R. Naber, Ryan L. Hartman, Jonathan P. McMullen, Klavs F. Jensen, Stephen L. Buchwald

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

A continuous-flow palladium-catalyzed amination reaction was made possible through efficient handling of solids via acoustic irradiation. Various diarylamines were obtained with reaction times ranging from 20 s to 10 min.

Original language	English (US)
Pages (from-to)	287-290
Number of pages	4
Journal	Chemical Science
Volume	2
Issue number	2
DOIs	https://doi.org/10.1039/c0sc00524j
State	Published - Feb 1 2011

ASJC Scopus subject areas

General Chemistry

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10.1039/c0sc00524j

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title = "Palladium-catalyzed amination reactions in flow: Overcoming the challenges of clogging via acoustic irradiation",

abstract = "A continuous-flow palladium-catalyzed amination reaction was made possible through efficient handling of solids via acoustic irradiation. Various diarylamines were obtained with reaction times ranging from 20 s to 10 min.",

author = "Timothy No{\^e}l and Naber, {John R.} and Hartman, {Ryan L.} and McMullen, {Jonathan P.} and Jensen, {Klavs F.} and Buchwald, {Stephen L.}",

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doi = "10.1039/c0sc00524j",

language = "English (US)",

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T2 - Overcoming the challenges of clogging via acoustic irradiation

AU - Noêl, Timothy

AU - Naber, John R.

AU - Hartman, Ryan L.

AU - McMullen, Jonathan P.

AU - Jensen, Klavs F.

AU - Buchwald, Stephen L.

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AB - A continuous-flow palladium-catalyzed amination reaction was made possible through efficient handling of solids via acoustic irradiation. Various diarylamines were obtained with reaction times ranging from 20 s to 10 min.

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Palladium-catalyzed amination reactions in flow: Overcoming the challenges of clogging via acoustic irradiation

Abstract

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