Abstract
Palladium-catalyzed C-H annulation reactions represent a compelling strategy to construct complex ring systems with high step economy. While there are many approaches to annulate structures by activation of a single C-H bond, transformations that proceed by activation of multiple C-H bonds are less explored. This is especially true for examples where one of the reacting C-H bonds is located at an sp3 center. However, exciting developments in palladium-catalyzed C-H activation continue to expand the scope of these transformations and provide innovative strategies to construct challenging carbon-carbon bonds. From these discoveries, sequential C-H activations have emerged as a powerful tool to access complex ring systems through the activation of C(sp2)-H/C(sp3)-H or C(sp3)-H/C(sp3)-H bonds. In this Perspective, we showcase recent examples that use this strategy in order to highlight the synthetic potential of C-H activation-enabled annulations and inspire future use of these disconnections for diverse scaffold synthesis.
Original language | English (US) |
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Pages (from-to) | 6535-6546 |
Number of pages | 12 |
Journal | ACS Catalysis |
Volume | 14 |
Issue number | 9 |
DOIs | |
State | Published - May 3 2024 |
Keywords
- annulation
- C−H activation
- oxidative coupling
- palladium
ASJC Scopus subject areas
- Catalysis
- General Chemistry