Palladium-Catalyzed Annulations via Sequential C-H Activations of C(sp2)-H/C(sp3)-H or C(sp3)-H/C(sp3)-H Bonds

Wan Xu Wei, Mateusz Czajkowski, Yangjin Kuang, Tu Anh V. Nguyen, Bo Qin, Martin Tomanik

Research output: Contribution to journalReview articlepeer-review


Palladium-catalyzed C-H annulation reactions represent a compelling strategy to construct complex ring systems with high step economy. While there are many approaches to annulate structures by activation of a single C-H bond, transformations that proceed by activation of multiple C-H bonds are less explored. This is especially true for examples where one of the reacting C-H bonds is located at an sp3 center. However, exciting developments in palladium-catalyzed C-H activation continue to expand the scope of these transformations and provide innovative strategies to construct challenging carbon-carbon bonds. From these discoveries, sequential C-H activations have emerged as a powerful tool to access complex ring systems through the activation of C(sp2)-H/C(sp3)-H or C(sp3)-H/C(sp3)-H bonds. In this Perspective, we showcase recent examples that use this strategy in order to highlight the synthetic potential of C-H activation-enabled annulations and inspire future use of these disconnections for diverse scaffold synthesis.

Original languageEnglish (US)
Pages (from-to)6535-6546
Number of pages12
JournalACS Catalysis
Issue number9
StatePublished - May 3 2024


  • annulation
  • C−H activation
  • oxidative coupling
  • palladium

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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