Palladium-catalyzed couplings to nucleophilic heteroarenes: The total synthesis of (-)-frondosin B

Chambers C. Hughes; Dirk Trauner

doi:10.1016/j.tet.2004.07.041

Palladium-catalyzed couplings to nucleophilic heteroarenes: The total synthesis of (-)-frondosin B

Chambers C. Hughes, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The total synthesis of (-)-frondosin B, the enantiomer of naturally-occuring (+)-frondosin B, is described, wherein a palladium-catalyzed cyclization is used to establish the tetracyclic ring system of the natural product. Graphical Abstract.

Original language	English (US)
Pages (from-to)	9675-9686
Number of pages	12
Journal	Tetrahedron
Volume	60
Issue number	43 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.tet.2004.07.041
State	Published - Oct 18 2004

Keywords

Frondosin
Heck reaction
Palladium catalysis
Total synthesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2004.07.041

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title = "Palladium-catalyzed couplings to nucleophilic heteroarenes: The total synthesis of (-)-frondosin B",

abstract = "The total synthesis of (-)-frondosin B, the enantiomer of naturally-occuring (+)-frondosin B, is described, wherein a palladium-catalyzed cyclization is used to establish the tetracyclic ring system of the natural product. Graphical Abstract.",

keywords = "Frondosin, Heck reaction, Palladium catalysis, Total synthesis",

author = "Hughes, {Chambers C.} and Dirk Trauner",

year = "2004",

month = oct,

day = "18",

doi = "10.1016/j.tet.2004.07.041",

language = "English (US)",

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journal = "Tetrahedron",

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T1 - Palladium-catalyzed couplings to nucleophilic heteroarenes

T2 - The total synthesis of (-)-frondosin B

AU - Hughes, Chambers C.

AU - Trauner, Dirk

PY - 2004/10/18

Y1 - 2004/10/18

N2 - The total synthesis of (-)-frondosin B, the enantiomer of naturally-occuring (+)-frondosin B, is described, wherein a palladium-catalyzed cyclization is used to establish the tetracyclic ring system of the natural product. Graphical Abstract.

AB - The total synthesis of (-)-frondosin B, the enantiomer of naturally-occuring (+)-frondosin B, is described, wherein a palladium-catalyzed cyclization is used to establish the tetracyclic ring system of the natural product. Graphical Abstract.

KW - Frondosin

KW - Heck reaction

KW - Palladium catalysis

KW - Total synthesis

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U2 - 10.1016/j.tet.2004.07.041

DO - 10.1016/j.tet.2004.07.041

M3 - Article

AN - SCOPUS:4544303936

SN - 0040-4020

VL - 60

SP - 9675

EP - 9686

JO - Tetrahedron

JF - Tetrahedron

IS - 43 SPEC. ISS.

ER -

Palladium-catalyzed couplings to nucleophilic heteroarenes: The total synthesis of (-)-frondosin B

Abstract

Keywords

ASJC Scopus subject areas

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