Palladium-catalyzed direct C-H arylation of enamides with simple arenes

Sreekumar Pankajakshan, Yun He Xu, Jun Kee Cheng, Man Ting Low, Teck Peng Loh

Research output: Contribution to journalArticle

Abstract

Z only: An atom-economical synthetic route towards arylated Z-enamides through double C-H functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B).

Original languageEnglish (US)
Pages (from-to)5701-5705
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number23
DOIs
StatePublished - Jun 4 2012

Keywords

  • C-H functionalization
  • arylation
  • enamides
  • palladium
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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