Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

Manikantha Maraswami, Sreekumar Pankajakshan, Gang Chen, Teck Peng Loh

Research output: Contribution to journalArticlepeer-review


A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.

Original languageEnglish (US)
Pages (from-to)4223-4226
Number of pages4
JournalOrganic Letters
Issue number16
StatePublished - Aug 18 2017

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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