The cyclization of γ, δ-unsaturated tertiary hydroperoxides in the presence of a palladium(II) catalyst afforded 1,2-dioxanes resembling biologically active natural products. A variety of substrates were screened, and synthetic manipulations were accomplished to construct compounds with structural similarity to antimalarial targets.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Aug 6 2009|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry