Palladium(II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1,2-dioxanes

Jason R. Harris, Shelli R. Waetzig, K. A. Woerpel

Research output: Contribution to journalArticle

Abstract

The cyclization of γ, δ-unsaturated tertiary hydroperoxides in the presence of a palladium(II) catalyst afforded 1,2-dioxanes resembling biologically active natural products. A variety of substrates were screened, and synthetic manipulations were accomplished to construct compounds with structural similarity to antimalarial targets.

Original languageEnglish (US)
Pages (from-to)3290-3293
Number of pages4
JournalOrganic Letters
Volume11
Issue number15
DOIs
StatePublished - Aug 6 2009

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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