TY - GEN
T1 - Paper based microarrays for 3D tumor spheroid modeling
AU - Alnemari, Roaa
AU - Sukumar, Pavithra
AU - Deliorman, Muhammedin
AU - Qasaimeh, Mohammad A.
N1 - Funding Information:
We acknowledge financial support from NYU Abu Dhabi, and technical support from NYUAD Core Technology Platforms.
Publisher Copyright:
Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - This work demonstrates forming tumor spheroids in 3D paper scaffolds in a microarray configuration. The patterns were fabricated by vaporizing the paper with Trichloro silane gas through a 3D printed stencil, generating hydrophobic and hydrophilic regions, where cells localize and grow to form spheroid structures. The technology is developed for high throughput spheroids formation and localizations within the 3D paper environment offering cost and time-effective tool for anti-cancer drug discovery applications.
AB - This work demonstrates forming tumor spheroids in 3D paper scaffolds in a microarray configuration. The patterns were fabricated by vaporizing the paper with Trichloro silane gas through a 3D printed stencil, generating hydrophobic and hydrophilic regions, where cells localize and grow to form spheroid structures. The technology is developed for high throughput spheroids formation and localizations within the 3D paper environment offering cost and time-effective tool for anti-cancer drug discovery applications.
KW - 3D cell culture
KW - Paper-based cell culture
KW - Spheroids
UR - http://www.scopus.com/inward/record.url?scp=85079765832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079765832&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85079765832
T3 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
SP - 1484
EP - 1486
BT - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PB - Chemical and Biological Microsystems Society
T2 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Y2 - 11 November 2018 through 15 November 2018
ER -