Paper based microarrays for 3D tumor spheroid modeling

Roaa Alnemari, Pavithra Sukumar, Muhammedin Deliorman, Mohammad A. Qasaimeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work demonstrates forming tumor spheroids in 3D paper scaffolds in a microarray configuration. The patterns were fabricated by vaporizing the paper with Trichloro silane gas through a 3D printed stencil, generating hydrophobic and hydrophilic regions, where cells localize and grow to form spheroid structures. The technology is developed for high throughput spheroids formation and localizations within the 3D paper environment offering cost and time-effective tool for anti-cancer drug discovery applications.

Original languageEnglish (US)
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages1484-1486
Number of pages3
ISBN (Electronic)9781510897571
StatePublished - Jan 1 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: Nov 11 2018Nov 15 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume3

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period11/11/1811/15/18

Keywords

  • 3D cell culture
  • Paper-based cell culture
  • Spheroids

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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