Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation

Yelena Margolin, Jean Francois Cloutier, Vladimir Shafirovich, Nicholas E. Geacintov, Peter C. Dedon

Research output: Contribution to journalArticle

Abstract

Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.

Original languageEnglish (US)
Pages (from-to)365-366
Number of pages2
JournalNature Chemical Biology
Volume2
Issue number7
DOIs
StatePublished - Jul 2006

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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