Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation

Yelena Margolin; Jean Francois Cloutier; Vladimir Shafirovich; Nicholas E. Geacintov; Peter C. Dedon

doi:10.1038/nchembio796

Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation

Yelena Margolin, Jean Francois Cloutier, Vladimir Shafirovich, Nicholas E. Geacintov, Peter C. Dedon

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO₂^-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.

Original language	English (US)
Pages (from-to)	365-366
Number of pages	2
Journal	Nature Chemical Biology
Volume	2
Issue number	7
DOIs	https://doi.org/10.1038/nchembio796
State	Published - Jul 2006

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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title = "Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation",

abstract = "Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.",

author = "Yelena Margolin and Cloutier, {Jean Francois} and Vladimir Shafirovich and Geacintov, {Nicholas E.} and Dedon, {Peter C.}",

note = "Funding Information: This research was supported by the National Cancer Institute (CA110261 and CA026731) and the National Institute of Environmental Health Sciences (ES002109).",

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AU - Cloutier, Jean Francois

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AU - Geacintov, Nicholas E.

AU - Dedon, Peter C.

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AB - Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.

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Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation

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