Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation

Yelena Margolin; Jean Francois Cloutier; Vladimir Shafirovich; Nicholas E. Geacintov; Peter C. Dedon

doi:10.1038/nchembio796

Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation

Yelena Margolin, Jean Francois Cloutier, Vladimir Shafirovich, Nicholas E. Geacintov, Peter C. Dedon

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO₂^-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.

Original language	English (US)
Pages (from-to)	365-366
Number of pages	2
Journal	Nature Chemical Biology
Volume	2
Issue number	7
DOIs	https://doi.org/10.1038/nchembio796
State	Published - Jul 2006

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Access to Document

10.1038/nchembio796

Cite this

@article{0e10c9cbc743453eae763266a3828ff3,

title = "Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation",

abstract = "Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.",

author = "Yelena Margolin and Cloutier, {Jean Francois} and Vladimir Shafirovich and Geacintov, {Nicholas E.} and Dedon, {Peter C.}",

note = "Funding Information: This research was supported by the National Cancer Institute (CA110261 and CA026731) and the National Institute of Environmental Health Sciences (ES002109).",

year = "2006",

month = jul,

doi = "10.1038/nchembio796",

language = "English (US)",

volume = "2",

pages = "365--366",

journal = "Nature Chemical Biology",

issn = "1552-4450",

publisher = "Nature Publishing Group",

number = "7",

}

TY - JOUR

T1 - Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation

AU - Margolin, Yelena

AU - Cloutier, Jean Francois

AU - Shafirovich, Vladimir

AU - Geacintov, Nicholas E.

AU - Dedon, Peter C.

N1 - Funding Information: This research was supported by the National Cancer Institute (CA110261 and CA026731) and the National Institute of Environmental Health Sciences (ES002109).

PY - 2006/7

Y1 - 2006/7

N2 - Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.

AB - Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.

UR - http://www.scopus.com/inward/record.url?scp=33745327259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745327259&partnerID=8YFLogxK

U2 - 10.1038/nchembio796

DO - 10.1038/nchembio796

M3 - Article

C2 - 16751762

AN - SCOPUS:33745327259

VL - 2

SP - 365

EP - 366

JO - Nature Chemical Biology

JF - Nature Chemical Biology

SN - 1552-4450

IS - 7

ER -

Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this