TY - JOUR
T1 - Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation
AU - Margolin, Yelena
AU - Cloutier, Jean Francois
AU - Shafirovich, Vladimir
AU - Geacintov, Nicholas E.
AU - Dedon, Peter C.
PY - 2006/7
Y1 - 2006/7
N2 - Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.
AB - Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.
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U2 - 10.1038/nchembio796
DO - 10.1038/nchembio796
M3 - Article
C2 - 16751762
AN - SCOPUS:33745327259
VL - 2
SP - 365
EP - 366
JO - Nature Chemical Biology
JF - Nature Chemical Biology
SN - 1552-4450
IS - 7
ER -