Abstract
Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2-) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.
Original language | English (US) |
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Pages (from-to) | 365-366 |
Number of pages | 2 |
Journal | Nature Chemical Biology |
Volume | 2 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2006 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology