TY - JOUR
T1 - Parahydrogen-Based Hyperpolarization for Biomedicine
AU - Hövener, Jan Bernd
AU - Pravdivtsev, Andrey N.
AU - Kidd, Bryce
AU - Bowers, C. Russell
AU - Glöggler, Stefan
AU - Kovtunov, Kirill V.
AU - Plaumann, Markus
AU - Katz-Brull, Rachel
AU - Buckenmaier, Kai
AU - Jerschow, Alexej
AU - Reineri, Francesca
AU - Theis, Thomas
AU - Shchepin, Roman V.
AU - Wagner, Shawn
AU - Bhattacharya, Pratip
AU - Zacharias, Niki M.
AU - Chekmenev, Eduard Y.
N1 - Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/8/27
Y1 - 2018/8/27
N2 - Magnetic resonance (MR) is one of the most versatile and useful physical effects used for human imaging, chemical analysis, and the elucidation of molecular structures. However, its full potential is rarely used, because only a small fraction of the nuclear spin ensemble is polarized, that is, aligned with the applied static magnetic field. Hyperpolarization methods seek other means to increase the polarization and thus the MR signal. A unique source of pure spin order is the entangled singlet spin state of dihydrogen, parahydrogen (pH2), which is inherently stable and long-lived. When brought into contact with another molecule, this “spin order on demand” allows the MR signal to be enhanced by several orders of magnitude. Considerable progress has been made in the past decade in the area of pH2-based hyperpolarization techniques for biomedical applications. It is the goal of this Review to provide a selective overview of these developments, covering the areas of spin physics, catalysis, instrumentation, preparation of the contrast agents, and applications.
AB - Magnetic resonance (MR) is one of the most versatile and useful physical effects used for human imaging, chemical analysis, and the elucidation of molecular structures. However, its full potential is rarely used, because only a small fraction of the nuclear spin ensemble is polarized, that is, aligned with the applied static magnetic field. Hyperpolarization methods seek other means to increase the polarization and thus the MR signal. A unique source of pure spin order is the entangled singlet spin state of dihydrogen, parahydrogen (pH2), which is inherently stable and long-lived. When brought into contact with another molecule, this “spin order on demand” allows the MR signal to be enhanced by several orders of magnitude. Considerable progress has been made in the past decade in the area of pH2-based hyperpolarization techniques for biomedical applications. It is the goal of this Review to provide a selective overview of these developments, covering the areas of spin physics, catalysis, instrumentation, preparation of the contrast agents, and applications.
KW - NMR spectroscopy
KW - hyperpolarization
KW - magnetic resonance imaging
KW - parahydrogen
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U2 - 10.1002/anie.201711842
DO - 10.1002/anie.201711842
M3 - Review article
C2 - 29484795
AN - SCOPUS:85051753174
SN - 1433-7851
VL - 57
SP - 11140
EP - 11162
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 35
ER -