Parahydrogen-Based Hyperpolarization for Biomedicine

Jan Bernd Hövener, Andrey N. Pravdivtsev, Bryce Kidd, C. Russell Bowers, Stefan Glöggler, Kirill V. Kovtunov, Markus Plaumann, Rachel Katz-Brull, Kai Buckenmaier, Alexej Jerschow, Francesca Reineri, Thomas Theis, Roman V. Shchepin, Shawn Wagner, Pratip Bhattacharya, Niki M. Zacharias, Eduard Y. Chekmenev

Research output: Contribution to journalReview articlepeer-review

Abstract

Magnetic resonance (MR) is one of the most versatile and useful physical effects used for human imaging, chemical analysis, and the elucidation of molecular structures. However, its full potential is rarely used, because only a small fraction of the nuclear spin ensemble is polarized, that is, aligned with the applied static magnetic field. Hyperpolarization methods seek other means to increase the polarization and thus the MR signal. A unique source of pure spin order is the entangled singlet spin state of dihydrogen, parahydrogen (pH2), which is inherently stable and long-lived. When brought into contact with another molecule, this “spin order on demand” allows the MR signal to be enhanced by several orders of magnitude. Considerable progress has been made in the past decade in the area of pH2-based hyperpolarization techniques for biomedical applications. It is the goal of this Review to provide a selective overview of these developments, covering the areas of spin physics, catalysis, instrumentation, preparation of the contrast agents, and applications.

Original languageEnglish (US)
Pages (from-to)11140-11162
Number of pages23
JournalAngewandte Chemie - International Edition
Volume57
Issue number35
DOIs
StatePublished - Aug 27 2018

Keywords

  • NMR spectroscopy
  • hyperpolarization
  • magnetic resonance imaging
  • parahydrogen

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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