Parathyroid hormone: A double-edged sword for bone metabolism

Ling Qin, Liza J. Raggatt, Nicola C. Partridge

Research output: Contribution to journalReview articlepeer-review


Parathyroid hormone (PTH) is the major hormone regulating calcium metabolism. It is also the only FDA-approved drug for osteoporosis treatment that stimulates bone formation when injected daily. However, continuous infusion of PTH causes severe bone loss in line with its known catabolic effects. Many studies to understand the dual effects of PTH have been carried out, and in recent years a growing number of molecular and cellular mechanisms underlying these effects have emerged. Here, we outline the present knowledge and conclude that the kinetics of administration and subsequent signaling probably account for the divergent actions of the hormone.

Original languageEnglish (US)
Pages (from-to)60-65
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number2
StatePublished - Mar 2004

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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