Parathyroid hormone stimulation of noncanonical Wnt signaling in bone

Marika K. Bergenstock; Nicola C. Partridge

doi:10.1196/annals.1402.047

Parathyroid hormone stimulation of noncanonical Wnt signaling in bone

Marika K. Bergenstock, Nicola C. Partridge

Molecular Pathobiology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In bone, parathyroid hormone (PTH) exerts either a catabolic or an anabolic effect depending on its method of administration. This paradoxical action has led to the use of PTH as an effective treatment for osteoporosis. The Wnt family of signaling proteins has a critical role in multiple events, which are necessary for proper animal development and survival, yet their exact method of action in bone remains elusive. We have uncovered a novel link between Wnt-4 and PTH. We think that, in bone, Wnt-4 signaling in response to PTH implicates cross-talk of multiple signaling pathways. This work hopes to further elucidate Wnt signaling in bone and provide greater understanding of PTH's anabolic effects in bone.

Original language	English (US)
Title of host publication	Skeletal Biology and Medicine, Part A
Subtitle of host publication	Aspects of Bone Morphogenesis and Remodeling
Publisher	Blackwell Publishing Inc.
Pages	354-359
Number of pages	6
ISBN (Print)	9781573316842
DOIs	https://doi.org/10.1196/annals.1402.047
State	Published - Nov 2007

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1116
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Bone
Osteoblasts
Parathyroid hormone
Wnt signaling
Wnt-4
β-catenin

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

Access to Document

10.1196/annals.1402.047

Cite this

Parathyroid hormone stimulation of noncanonical Wnt signaling in bone. / Bergenstock, Marika K.; Partridge, Nicola C.
Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling. Blackwell Publishing Inc., 2007. p. 354-359 (Annals of the New York Academy of Sciences; Vol. 1116).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - In bone, parathyroid hormone (PTH) exerts either a catabolic or an anabolic effect depending on its method of administration. This paradoxical action has led to the use of PTH as an effective treatment for osteoporosis. The Wnt family of signaling proteins has a critical role in multiple events, which are necessary for proper animal development and survival, yet their exact method of action in bone remains elusive. We have uncovered a novel link between Wnt-4 and PTH. We think that, in bone, Wnt-4 signaling in response to PTH implicates cross-talk of multiple signaling pathways. This work hopes to further elucidate Wnt signaling in bone and provide greater understanding of PTH's anabolic effects in bone.

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Parathyroid hormone stimulation of noncanonical Wnt signaling in bone

Abstract

Publication series

Keywords

ASJC Scopus subject areas

Access to Document

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