Parkinson's Disease: A Thalamostriatal Rebalancing Act?

Nicolas X. Tritsch, Adam G. Carter

Research output: Contribution to journalShort survey

Abstract

Motor impairments in Parkinson's disease are thought to result from hypoactivation of striatal projection neurons in the direct pathway. In this issue of Neuron, Parker et al. (2016) report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these neurons, implicating the thalamus as playing a key role in Parkinsonian motor symptoms. Motor impairments in Parkinson's disease are thought to result from hypoactivation of striatal projection neurons in the direct pathway. Parker et al. report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these neurons, implicating the thalamus as playing a key role in Parkinsonian motor symptoms.

Original languageEnglish (US)
Pages (from-to)675-677
Number of pages3
JournalNeuron
Volume89
Issue number4
DOIs
StatePublished - Feb 17 2016

ASJC Scopus subject areas

  • Neuroscience(all)

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