Parkinson's Disease: A Thalamostriatal Rebalancing Act?

Nicolas X. Tritsch; Adam G. Carter

doi:10.1016/j.neuron.2016.02.008

Parkinson's Disease: A Thalamostriatal Rebalancing Act?

Nicolas X. Tritsch, Adam G. Carter

Neural Science

Research output: Contribution to journal › Short survey › peer-review

Abstract

Motor impairments in Parkinson's disease are thought to result from hypoactivation of striatal projection neurons in the direct pathway. In this issue of Neuron, Parker et al. (2016) report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these neurons, implicating the thalamus as playing a key role in Parkinsonian motor symptoms. Motor impairments in Parkinson's disease are thought to result from hypoactivation of striatal projection neurons in the direct pathway. Parker et al. report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these neurons, implicating the thalamus as playing a key role in Parkinsonian motor symptoms.

Original language	English (US)
Pages (from-to)	675-677
Number of pages	3
Journal	Neuron
Volume	89
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2016.02.008
State	Published - Feb 17 2016

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2016.02.008

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title = "Parkinson's Disease: A Thalamostriatal Rebalancing Act?",

abstract = "Motor impairments in Parkinson's disease are thought to result from hypoactivation of striatal projection neurons in the direct pathway. In this issue of Neuron, Parker et al. (2016) report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these neurons, implicating the thalamus as playing a key role in Parkinsonian motor symptoms. Motor impairments in Parkinson's disease are thought to result from hypoactivation of striatal projection neurons in the direct pathway. Parker et al. report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these neurons, implicating the thalamus as playing a key role in Parkinsonian motor symptoms.",

author = "Tritsch, {Nicolas X.} and Carter, {Adam G.}",

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year = "2016",

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AU - Carter, Adam G.

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N2 - Motor impairments in Parkinson's disease are thought to result from hypoactivation of striatal projection neurons in the direct pathway. In this issue of Neuron, Parker et al. (2016) report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these neurons, implicating the thalamus as playing a key role in Parkinsonian motor symptoms. Motor impairments in Parkinson's disease are thought to result from hypoactivation of striatal projection neurons in the direct pathway. Parker et al. report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these neurons, implicating the thalamus as playing a key role in Parkinsonian motor symptoms.

AB - Motor impairments in Parkinson's disease are thought to result from hypoactivation of striatal projection neurons in the direct pathway. In this issue of Neuron, Parker et al. (2016) report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these neurons, implicating the thalamus as playing a key role in Parkinsonian motor symptoms. Motor impairments in Parkinson's disease are thought to result from hypoactivation of striatal projection neurons in the direct pathway. Parker et al. report that dopamine depletion selectively weakens thalamic but not cortical afferents onto these neurons, implicating the thalamus as playing a key role in Parkinsonian motor symptoms.

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Parkinson's Disease: A Thalamostriatal Rebalancing Act?

Abstract

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