Pathological biomineralization of kidney stones

Jeffrey A. Wesson, Michael D. Ward

Research output: Contribution to journalArticlepeer-review

Abstract

Kidney stones are aggregates of microcrystals, most commonly containing calcium oxalate monohydrate (COM) as the primary constituent. The formation of these aggregates in the renal tubules of the kidney and their attachment to epithelial cells lining the renal tubules are thought to involve adhesion events between COM crystal surfaces and urinary species that bind to these surfaces. The pathological behavior of COM is in stark contrast to calcium oxalate dihydrate (COD), a different mineral phase commonly found in voided urine but much less frequently in stones, and whose presence is thought to protect against stone formation. This observation suggests that the structure and composition of calcium oxalate crystal surfaces and the fundamental interactions of these surfaces with urinary species are crucial to unraveling the complex pathology of this debilitating disease.

Original languageEnglish (US)
Pages (from-to)415-421
Number of pages7
JournalElements
Volume3
Issue number6
DOIs
StatePublished - Dec 2007

Keywords

  • Atomic force microscopy
  • Biomineralization
  • Calcium oxalate
  • Kidney stone

ASJC Scopus subject areas

  • Geochemistry and Petrology
  • Earth and Planetary Sciences (miscellaneous)

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