Pathways for protein folding: Is a new view needed?

Vijay S. Pande, Alexander Yu Grosberg, Toyoichi Tanaka, Daniel S. Rokhsar

    Research output: Contribution to journalArticle

    Abstract

    Theoretical studies using simplified models of proteins have shed light on the general heteropolymeric aspects of the folding problem. Recent work has emphasized the statistical aspects of folding pathways. In particular, progress has been made in characterizing the ensemble of transition state conformations and elucidating the role of intermediates. These advances suggest a reconciliation between the new ensemble approaches and the classical view of a folding pathway.

    Original languageEnglish (US)
    Pages (from-to)68-79
    Number of pages12
    JournalCurrent Opinion in Structural Biology
    Volume8
    Issue number1
    DOIs
    StatePublished - Feb 1998

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    ASJC Scopus subject areas

    • Structural Biology
    • Molecular Biology

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