Pausing on the Path to Robustness

Mark L. Siegal; Christine Rushlow

doi:10.1016/j.devcel.2012.04.020

Pausing on the Path to Robustness

Mark L. Siegal, Christine Rushlow

Biology and Genomics

Research output: Contribution to journal › Short survey › peer-review

Abstract

Heat-shock proteins (Hsps) maintain homeostasis by assisting protein folding, and the transcriptional regulation of Hsp-coding genes has long been under study. Sawarkar et al. (2012) now report in Cell that Hsp90 is itself a transcriptional regulator required for RNA polymerase pausing, contributing to rapid, robust induction of many genes.

Original language	English (US)
Pages (from-to)	905-906
Number of pages	2
Journal	Developmental Cell
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2012.04.020
State	Published - May 15 2012

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Developmental Biology
Cell Biology

Access to Document

10.1016/j.devcel.2012.04.020

Cite this

@article{822c7d99418845eba7f352f1e737fdb8,

title = "Pausing on the Path to Robustness",

abstract = "Heat-shock proteins (Hsps) maintain homeostasis by assisting protein folding, and the transcriptional regulation of Hsp-coding genes has long been under study. Sawarkar et al. (2012) now report in Cell that Hsp90 is itself a transcriptional regulator required for RNA polymerase pausing, contributing to rapid, robust induction of many genes.",

author = "Siegal, {Mark L.} and Christine Rushlow",

year = "2012",

month = may,

day = "15",

doi = "10.1016/j.devcel.2012.04.020",

language = "English (US)",

volume = "22",

pages = "905--906",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "5",

}

TY - JOUR

T1 - Pausing on the Path to Robustness

AU - Siegal, Mark L.

AU - Rushlow, Christine

PY - 2012/5/15

Y1 - 2012/5/15

N2 - Heat-shock proteins (Hsps) maintain homeostasis by assisting protein folding, and the transcriptional regulation of Hsp-coding genes has long been under study. Sawarkar et al. (2012) now report in Cell that Hsp90 is itself a transcriptional regulator required for RNA polymerase pausing, contributing to rapid, robust induction of many genes.

AB - Heat-shock proteins (Hsps) maintain homeostasis by assisting protein folding, and the transcriptional regulation of Hsp-coding genes has long been under study. Sawarkar et al. (2012) now report in Cell that Hsp90 is itself a transcriptional regulator required for RNA polymerase pausing, contributing to rapid, robust induction of many genes.

UR - http://www.scopus.com/inward/record.url?scp=84860902926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860902926&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2012.04.020

DO - 10.1016/j.devcel.2012.04.020

M3 - Short survey

C2 - 22595664

AN - SCOPUS:84860902926

SN - 1534-5807

VL - 22

SP - 905

EP - 906

JO - Developmental Cell

JF - Developmental Cell

IS - 5

ER -

Pausing on the Path to Robustness

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this