Pausing on the Path to Robustness

Mark L. Siegal; Christine Rushlow

doi:10.1016/j.devcel.2012.04.020

Pausing on the Path to Robustness

Mark L. Siegal, Christine Rushlow

Biology and Genomics

Research output: Contribution to journal › Short survey › peer-review

Abstract

Heat-shock proteins (Hsps) maintain homeostasis by assisting protein folding, and the transcriptional regulation of Hsp-coding genes has long been under study. Sawarkar et al. (2012) now report in Cell that Hsp90 is itself a transcriptional regulator required for RNA polymerase pausing, contributing to rapid, robust induction of many genes.

Original language	English (US)
Pages (from-to)	905-906
Number of pages	2
Journal	Developmental Cell
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2012.04.020
State	Published - May 15 2012

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2012.04.020

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title = "Pausing on the Path to Robustness",

abstract = "Heat-shock proteins (Hsps) maintain homeostasis by assisting protein folding, and the transcriptional regulation of Hsp-coding genes has long been under study. Sawarkar et al. (2012) now report in Cell that Hsp90 is itself a transcriptional regulator required for RNA polymerase pausing, contributing to rapid, robust induction of many genes.",

author = "Siegal, {Mark L.} and Christine Rushlow",

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doi = "10.1016/j.devcel.2012.04.020",

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AU - Siegal, Mark L.

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AB - Heat-shock proteins (Hsps) maintain homeostasis by assisting protein folding, and the transcriptional regulation of Hsp-coding genes has long been under study. Sawarkar et al. (2012) now report in Cell that Hsp90 is itself a transcriptional regulator required for RNA polymerase pausing, contributing to rapid, robust induction of many genes.

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JO - Developmental Cell

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Pausing on the Path to Robustness

Abstract

ASJC Scopus subject areas

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