Pax genes and eye organogenesis

Franck Pichaud, Claude Desplan

Research output: Contribution to journalReview articlepeer-review


Pax6 is a highly conserved gene that controls eye development in all species where it has been tested. In spite of this common 'master control regulator', the eyes of different animals are morphologically very different and it is believed that they have evolved independently multiple times through evolution. Recent works looking at eye development in 'primitive' species offer some explanation as to the surprising amount of conservation in genetic and morphogenetic pathways involved in eye development. These studies not only implicate the Pax genes but also the So/Six gene family in playing a crucial ancestral role in visual system development.

Original languageEnglish (US)
Pages (from-to)430-434
Number of pages5
JournalCurrent Opinion in Genetics and Development
Issue number4
StatePublished - Aug 1 2002

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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