Peptide hydrogenation and labeling with parahydrogen

Francesca Gruppi, Xiang Xu, Boyang Zhang, Joel A. Tang, Alexej Jerschow, James W. Canary

Research output: Contribution to journalArticle

Abstract

Site-specific spin polarization labeling of a peptide was conducted by homogeneous hydrogenation with parahydrogen. Surprisingly, polarization transfer to a remote alanine residue was observed. The diastereoselectivity of the hydrogenation reaction was determined, and these results show that parahydrogen can be used to enhance signals and elucidate the hydrogenation processes of dehydropeptide units in complex molecules.

Original languageEnglish (US)
Pages (from-to)11787-11790
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number47
DOIs
StatePublished - Nov 19 2012

Keywords

  • NMR spectroscopy
  • hydrogenation
  • hyperpolarization
  • parahydrogen
  • peptides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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