Peptide hydrogenation and labeling with parahydrogen

Francesca Gruppi; Xiang Xu; Boyang Zhang; Joel A. Tang; Alexej Jerschow; James W. Canary

doi:10.1002/anie.201204403

Peptide hydrogenation and labeling with parahydrogen

Francesca Gruppi, Xiang Xu, Boyang Zhang, Joel A. Tang, Alexej Jerschow, James W. Canary

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Site-specific spin polarization labeling of a peptide was conducted by homogeneous hydrogenation with parahydrogen. Surprisingly, polarization transfer to a remote alanine residue was observed. The diastereoselectivity of the hydrogenation reaction was determined, and these results show that parahydrogen can be used to enhance signals and elucidate the hydrogenation processes of dehydropeptide units in complex molecules.

Original language	English (US)
Pages (from-to)	11787-11790
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	47
DOIs	https://doi.org/10.1002/anie.201204403
State	Published - Nov 19 2012

Keywords

NMR spectroscopy
hydrogenation
hyperpolarization
parahydrogen
peptides

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201204403

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abstract = "Site-specific spin polarization labeling of a peptide was conducted by homogeneous hydrogenation with parahydrogen. Surprisingly, polarization transfer to a remote alanine residue was observed. The diastereoselectivity of the hydrogenation reaction was determined, and these results show that parahydrogen can be used to enhance signals and elucidate the hydrogenation processes of dehydropeptide units in complex molecules.",

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author = "Francesca Gruppi and Xiang Xu and Boyang Zhang and Tang, {Joel A.} and Alexej Jerschow and Canary, {James W.}",

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T1 - Peptide hydrogenation and labeling with parahydrogen

AU - Gruppi, Francesca

AU - Xu, Xiang

AU - Zhang, Boyang

AU - Tang, Joel A.

AU - Jerschow, Alexej

AU - Canary, James W.

PY - 2012/11/19

Y1 - 2012/11/19

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AB - Site-specific spin polarization labeling of a peptide was conducted by homogeneous hydrogenation with parahydrogen. Surprisingly, polarization transfer to a remote alanine residue was observed. The diastereoselectivity of the hydrogenation reaction was determined, and these results show that parahydrogen can be used to enhance signals and elucidate the hydrogenation processes of dehydropeptide units in complex molecules.

KW - NMR spectroscopy

KW - hydrogenation

KW - hyperpolarization

KW - parahydrogen

KW - peptides

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JF - Angewandte Chemie - International Edition

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Peptide hydrogenation and labeling with parahydrogen

Abstract

Keywords

ASJC Scopus subject areas

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