@article{9e9dc50c0ab14e9c884020a05b81d406,
title = "Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity",
abstract = "An interruption in Aβ homeostasis leads to the deposit of neurotoxic amyloid plaques and is associated with Alzheimer's disease. A supramolecular strategy based on the assembly of peptidomimetic agents into functional vesicles has been conceived for the simultaneous inhibition of Aβ42 fibrillation and expedited clearance of Aβ42 aggregates. Tris-pyrrolamide peptidomimetic, ADH-353, contains one hydrophobic N-butyl and two hydrophilic N-propylamine side chains and readily forms vesicles under physiological conditions. These vesicles completely rescue both mouse neuroblastoma N2a and human neuroblastoma SH-SY5Y cells from the cytotoxicity that follows from Aβ42 misfolding likely in mitochondria. Biophysical studies, including confocal imaging, demonstrate the biocompatibility and selectivity of the approach toward this aberrant protein assembly in cellular milieu. ",
author = "Debabrata Maity and Madeline Howarth and Vogel, {Maria C.} and Mazin Magzoub and Hamilton, {Andrew D.}",
note = "Funding Information: We thank the NYU Langone Health DART Microscopy Lab for their assistance with TEM work. This core is partially funded by NYU Cancer Center Support grant NIH/NCI P30CA016087. We also thank Dr. Chunhua T. Hu at the X-ray Diffraction Facility of NYU Department of Chemistry for his help and Dr. L. Palanikumar (NYU Abu Dhabi) for assistance with the cell culture. Confocal imaging was carried out using the Core Technology Platforms (CTP) resources at NYU Abu Dhabi. Dr. Chunhua T. Hu acknowledges the support of the National Science Foundation (NSF) Chemistry Research Instrumentation and Facilities Program (CHE-0840277) and the Materials Research Science and Engineering Center (MRSEC) Program (DMR-1420073). This work was supported by funding from New York University to Andrew D. Hamilton and from New York University Abu Dhabi to Mazin Magzoub. Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",
year = "2021",
month = mar,
day = "3",
doi = "10.1021/jacs.0c09967",
language = "English (US)",
volume = "143",
pages = "3086--3093",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "8",
}