TY - JOUR
T1 - Peptidomimetic inhibitors of p21ras farnesyltransferase
T2 - Hydrophobic functionalization leads to disruption of p21ras membrane association in whole cells
AU - Qian, Yimin
AU - Blaskovich, Michelle A.
AU - Seong, Churl Min
AU - Vogt, Andreas
AU - Hamilton, Andrew D.
AU - Sebti, Said M.
PY - 1994/11/10
Y1 - 1994/11/10
N2 - In this paper we describe the synthesis of several hydrophobic inhibitors of p21ras farnesyltransferase. These peptidomimetic structures, containing cysteine and methionine residues separated by an aromatic spacer, are functionalized as their methyl esters and N,S-bis-benzyloxycarbonyl (Cbz) derivatives and are shown to penetrate NIH 3T3 cells to disrupt p21 ras plasma membrane association.
AB - In this paper we describe the synthesis of several hydrophobic inhibitors of p21ras farnesyltransferase. These peptidomimetic structures, containing cysteine and methionine residues separated by an aromatic spacer, are functionalized as their methyl esters and N,S-bis-benzyloxycarbonyl (Cbz) derivatives and are shown to penetrate NIH 3T3 cells to disrupt p21 ras plasma membrane association.
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U2 - 10.1016/S0960-894X(01)80287-0
DO - 10.1016/S0960-894X(01)80287-0
M3 - Article
AN - SCOPUS:0028132044
SN - 0960-894X
VL - 4
SP - 2579
EP - 2584
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 21
ER -