Peptoid macrocycles: making the rounds with peptidomimetic oligomers

Barney Yoo, Sung Bin Y. Shin, Mia Lace Huang, Kent Kirshenbaum

Research output: Contribution to journalReview articlepeer-review


Macrocyclic constraints are often employed to rigidify the conformation of flexible oligomeric systems. This approach has recently been used to organize the structure of peptoid oligomers, which are peptidomimetics composed of chemically diverse N-substituted glycine monomer units. In this review, we describe advances in the synthesis and characterization of cyclic peptoids. We evaluate how the installation of covalent constraints between the oligomer termini or side chains has been effective in defining peptoid conformations. We also discuss the potential applications for this promising family of macrocyclic peptidomimetics.

Original languageEnglish (US)
Pages (from-to)5528-5537
Number of pages10
JournalChemistry - A European Journal
Issue number19
StatePublished - May 17 2010


  • Foldamers
  • Macrocycles
  • Peptidomimetics
  • Peptoids

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis
  • Organic Chemistry


Dive into the research topics of 'Peptoid macrocycles: making the rounds with peptidomimetic oligomers'. Together they form a unique fingerprint.

Cite this