Performance of degradable composite bone repair products made via three-dimensional fabrication techniques

Tithi Dutta Roy, Joshua L. Simon, John L. Ricci, E. Dianne Rekow, Van P. Thompson, J. Russell Parsons

Research output: Contribution to journalArticlepeer-review

Abstract

This study analyzed the in vivo performance of composite degradable bone repair products fabricated using the TheriForm™ process, a solid freeform fabrication (SFF) technique, in a rabbit calvarial defect model at 8 weeks. Scaffolds were composed of polylactic-co-glycolic acid (PLGA) polymer with 20% w/w β-tricalcium phosphate (β-TCP) ceramic with engineered macroscopic channels, a controlled porosity gradient, and a controlled pore size for promotion of new bone ingrowth. Scaffolds with engineered macroscopic channels and a porosity gradient had higher percentages of new bone area compared to scaffolds without engineered channels. These scaffolds also had higher percentages of new bone area compared to unfilled control defects, suggesting that scaffold material and design combinations could be tailored to facilitate filling of bony defects. This proof-of-concept study demonstrated that channel size, porosity, and pore size can be controlled and used to influence new bone formation and calvarial defect healing.

Original languageEnglish (US)
Pages (from-to)283-291
Number of pages9
JournalJournal of Biomedical Materials Research - Part A
Volume66
Issue number2
DOIs
StatePublished - Aug 1 2003

Keywords

  • Bone graft
  • PLGA
  • Scaffold fabrication
  • Solid freeform fabrication
  • Tissue engineering

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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