Performance of hydroxyapatite bone repair scaffolds created via three-dimensional fabrication techniques

Tithi Dutta Roy, Joshua L. Simon, John L. Ricci, E. Dianne Rekow, Van P. Thompson, J. Russell Parsons

Research output: Contribution to journalArticle

Abstract

The current study analyzes the in vivo performance of porous sintered hydroxyapatite (HA) bone repair scaffolds fabricated using the TheriForm™ solid freeform fabrication process. Porous HA scaffolds with engineered macroscopic channels had a significantly higher percentage of new bone area compared with porous HA scaffolds without channels in a rabbit calvarial defect model at an 8-week time point. An unexpected finding was the unusually large amount of new bone within the base material structure, which contained pores less than 20 μm in size. Compared with composite scaffolds of 80% polylactic-co-glycolic acid and 20% β-tricalcium phosphate with the same macroscopic architecture as evaluated in a previous study, the porous HA scaffolds with channels had a significantly higher percentage of new bone area. Therefore, the current study indicates that scaffold geometry, as determined by the fabrication process, can enhance the ability of a ceramic material to accelerate healing of calvarial defects.

Original languageEnglish (US)
Pages (from-to)1228-1237
Number of pages10
JournalJournal of Biomedical Materials Research - Part A
Volume67
Issue number4
StatePublished - Dec 15 2003

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Keywords

  • Bone graft
  • Hydroxyapatite
  • Scaffold fabrication
  • Solid freeform fabrication
  • Tissue engineering

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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