Periodontal disease as a possible cause for Alzheimer's disease

Angela R. Kamer, Ronald G. Craig, Richard Niederman, Juan Fortea, Mony J. de Leon

Research output: Contribution to journalReview articlepeer-review


Approximately 47 million people worldwide have been diagnosed with dementia, 60%-80% of whom have dementia of the Alzheimer’s disease type. Unfortunately, there is no cure in sight. Defining modifiable risk factors for Alzheimer’s disease may have a significant impact on its prevalence. An increasing body of evidence suggests that chronic inflammation and microbial dysbiosis are risk factors for Alzheimer’s disease. Periodontal disease is a chronic inflammatory disease that develops in response to response to microbial dysbiosis. Many studies have shown an association between periodontal disease and Alzheimer’s disease. The intent of this paper was to review the existing literature and determine, using the Bradford Hill criteria, whether periodontal disease is causally related to Alzheimer’s disease.

Original languageEnglish (US)
Pages (from-to)242-271
Number of pages30
JournalPeriodontology 2000
Issue number1
StatePublished - Jun 1 2020

ASJC Scopus subject areas

  • Periodontics


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