Periodontal diseases and carotid intima-media thickness in Bangladesh

Fen Wu; Yu Chen; Ryan T. Demmer; Faruque Parvez; Rina Rani Paul; Ishrat Shaheen; Golam Sarwar; Alauddin Ahmed; Mahbub Eunus; Nafiz Ahsan; Nur Mohammad Habibullah; Tariqul Islam; Tatjana Rundek; Habibul Ahsan; Moise Desvarieux

doi:10.1111/jcpe.12597

Periodontal diseases and carotid intima-media thickness in Bangladesh

Fen Wu, Yu Chen, Ryan T. Demmer, Faruque Parvez, Rina Rani Paul, Ishrat Shaheen, Golam Sarwar, Alauddin Ahmed, Mahbub Eunus, Nafiz Ahsan, Nur Mohammad Habibullah, Tariqul Islam, Tatjana Rundek, Habibul Ahsan, Moise Desvarieux

Urban Initiative

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: To evaluate the relationship between periodontal diseases and subclinical atherosclerosis in a younger and lean South Asian population.

METHODS: We conducted a cross-sectional study in 917 subjects (mean age 46 years and mean body mass index 21.1 kg/m2 ) from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Multivariate linear regression models were used to assess the associations between multiple clinical measures of periodontal diseases and carotid intima-media thickness (IMT).

RESULTS: Mean attachment loss (AL) and percentage of sites with AL ≥ 4 mm (% AL ≥ 4) were associated with increased IMT. The IMT was 20.0-μm (95% CI: 2.2, 37.8) and 26.5-μm (95% CI: 8.9, 44.1) higher in subjects in the top quartile of mean AL (>3.72 mm) and % AL ≥ 4 (>58.4%), respectively, compared to those in the bottom quartile. In a subset of 366 subjects, mean AL was positively associated with plasma levels of matrix metalloproteinase-9 (p < 0.05) and soluble intercellular adhesion molecule-1 (p < 0.01).

CONCLUSIONS: Attachment loss was associated with subclinical atherosclerosis in this young and lean Bangladeshi population. Future prospective studies are needed to confirm this association.

Original language	English (US)
Pages (from-to)	909-917
Number of pages	9
Journal	Journal of clinical periodontology
Volume	43
Issue number	11
DOIs	https://doi.org/10.1111/jcpe.12597
State	Published - Nov 1 2016

Keywords

Bangladesh
atherosclerosis
cardiovascular disease
carotid intima-media thickness
periodontal diseases

ASJC Scopus subject areas

Periodontics

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10.1111/jcpe.12597

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title = "Periodontal diseases and carotid intima-media thickness in Bangladesh",

abstract = "AIM: To evaluate the relationship between periodontal diseases and subclinical atherosclerosis in a younger and lean South Asian population.METHODS: We conducted a cross-sectional study in 917 subjects (mean age 46 years and mean body mass index 21.1 kg/m2 ) from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Multivariate linear regression models were used to assess the associations between multiple clinical measures of periodontal diseases and carotid intima-media thickness (IMT).RESULTS: Mean attachment loss (AL) and percentage of sites with AL ≥ 4 mm (% AL ≥ 4) were associated with increased IMT. The IMT was 20.0-μm (95% CI: 2.2, 37.8) and 26.5-μm (95% CI: 8.9, 44.1) higher in subjects in the top quartile of mean AL (>3.72 mm) and % AL ≥ 4 (>58.4%), respectively, compared to those in the bottom quartile. In a subset of 366 subjects, mean AL was positively associated with plasma levels of matrix metalloproteinase-9 (p < 0.05) and soluble intercellular adhesion molecule-1 (p < 0.01).CONCLUSIONS: Attachment loss was associated with subclinical atherosclerosis in this young and lean Bangladeshi population. Future prospective studies are needed to confirm this association.",

keywords = "Bangladesh, atherosclerosis, cardiovascular disease, carotid intima-media thickness, periodontal diseases",

author = "Fen Wu and Yu Chen and Demmer, {Ryan T.} and Faruque Parvez and Paul, {Rina Rani} and Ishrat Shaheen and Golam Sarwar and Alauddin Ahmed and Mahbub Eunus and Nafiz Ahsan and Habibullah, {Nur Mohammad} and Tariqul Islam and Tatjana Rundek and Habibul Ahsan and Moise Desvarieux",

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doi = "10.1111/jcpe.12597",

language = "English (US)",

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TY - JOUR

T1 - Periodontal diseases and carotid intima-media thickness in Bangladesh

AU - Wu, Fen

AU - Chen, Yu

AU - Demmer, Ryan T.

AU - Parvez, Faruque

AU - Paul, Rina Rani

AU - Shaheen, Ishrat

AU - Sarwar, Golam

AU - Ahmed, Alauddin

AU - Eunus, Mahbub

AU - Ahsan, Nafiz

AU - Habibullah, Nur Mohammad

AU - Islam, Tariqul

AU - Rundek, Tatjana

AU - Ahsan, Habibul

AU - Desvarieux, Moise

PY - 2016/11/1

Y1 - 2016/11/1

N2 - AIM: To evaluate the relationship between periodontal diseases and subclinical atherosclerosis in a younger and lean South Asian population.METHODS: We conducted a cross-sectional study in 917 subjects (mean age 46 years and mean body mass index 21.1 kg/m2 ) from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Multivariate linear regression models were used to assess the associations between multiple clinical measures of periodontal diseases and carotid intima-media thickness (IMT).RESULTS: Mean attachment loss (AL) and percentage of sites with AL ≥ 4 mm (% AL ≥ 4) were associated with increased IMT. The IMT was 20.0-μm (95% CI: 2.2, 37.8) and 26.5-μm (95% CI: 8.9, 44.1) higher in subjects in the top quartile of mean AL (>3.72 mm) and % AL ≥ 4 (>58.4%), respectively, compared to those in the bottom quartile. In a subset of 366 subjects, mean AL was positively associated with plasma levels of matrix metalloproteinase-9 (p < 0.05) and soluble intercellular adhesion molecule-1 (p < 0.01).CONCLUSIONS: Attachment loss was associated with subclinical atherosclerosis in this young and lean Bangladeshi population. Future prospective studies are needed to confirm this association.

AB - AIM: To evaluate the relationship between periodontal diseases and subclinical atherosclerosis in a younger and lean South Asian population.METHODS: We conducted a cross-sectional study in 917 subjects (mean age 46 years and mean body mass index 21.1 kg/m2 ) from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Multivariate linear regression models were used to assess the associations between multiple clinical measures of periodontal diseases and carotid intima-media thickness (IMT).RESULTS: Mean attachment loss (AL) and percentage of sites with AL ≥ 4 mm (% AL ≥ 4) were associated with increased IMT. The IMT was 20.0-μm (95% CI: 2.2, 37.8) and 26.5-μm (95% CI: 8.9, 44.1) higher in subjects in the top quartile of mean AL (>3.72 mm) and % AL ≥ 4 (>58.4%), respectively, compared to those in the bottom quartile. In a subset of 366 subjects, mean AL was positively associated with plasma levels of matrix metalloproteinase-9 (p < 0.05) and soluble intercellular adhesion molecule-1 (p < 0.01).CONCLUSIONS: Attachment loss was associated with subclinical atherosclerosis in this young and lean Bangladeshi population. Future prospective studies are needed to confirm this association.

KW - Bangladesh

KW - atherosclerosis

KW - cardiovascular disease

KW - carotid intima-media thickness

KW - periodontal diseases

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JO - Journal of clinical periodontology

JF - Journal of clinical periodontology

IS - 11

ER -

Periodontal diseases and carotid intima-media thickness in Bangladesh

Abstract

Keywords

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