Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome

Angela R. Kamer; Juan O. Fortea; Sebastià Videla; Angela Mayoral; Malvin Janal; Maria Carmona-Iragui; Bessy Benejam; Ronald G. Craig; Deepak Saxena; Patricia Corby; Lidia Glodzik; Kumar Raghava Chowdary Annam; Miriam Robbins; Mony J. de Leon

doi:10.1016/j.dadm.2016.01.001

Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome

Angela R. Kamer, Juan O. Fortea, Sebastià Videla, Angela Mayoral, Malvin Janal, Maria Carmona-Iragui, Bessy Benejam, Ronald G. Craig, Deepak Saxena, Patricia Corby, Lidia Glodzik, Kumar Raghava Chowdary Annam, Miriam Robbins, Mony J. de Leon

Research output: Contribution to journal › Review article › peer-review

Abstract

People with Down syndrome (DS) are at an increased risk for Alzheimer's disease (AD). After 60 years of age, >50% of DS subjects acquire dementia. Nevertheless, the age of onset is highly variable possibly because of both genetic and environmental factors. Genetics cannot be modified, but environmental risk factors present a potentially relevant intervention for DS persons at risk for AD. Among them, inflammation, important in AD of DS type, is potential target. Consistent with this hypothesis, chronic peripheral inflammation and infections may contribute to AD pathogenesis in DS. People with DS have an aggressive form of periodontitis characterized by rapid progression, significant bacterial and inflammatory burden, and an onset as early as 6 years of age. This review offers a hypothetical mechanistic link between periodontitis and AD in the DS population. Because periodontitis is a treatable condition, it may be a readily modifiable risk factor for AD.

Original language	English (US)
Pages (from-to)	49-57
Number of pages	9
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	2
DOIs	https://doi.org/10.1016/j.dadm.2016.01.001
State	Published - 2016

Keywords

Aggressive periodontal disease
Alzheimer's disease
Down syndrome
Dysbiosis
Infection
Inflammation
Neuroinflammation
Periodontal disease
Trisomy 21

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1016/j.dadm.2016.01.001

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Kamer, A. R., Fortea, J. O., Videla, S., Mayoral, A., Janal, M., Carmona-Iragui, M., Benejam, B., Craig, R. G., Saxena, D., Corby, P., Glodzik, L., Annam, K. R. C., Robbins, M., & de Leon, M. J. (2016). Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 2, 49-57. https://doi.org/10.1016/j.dadm.2016.01.001

Kamer, AR, Fortea, JO, Videla, S, Mayoral, A, Janal, M, Carmona-Iragui, M, Benejam, B, Craig, RG, Saxena, D, Corby, P, Glodzik, L, Annam, KRC, Robbins, M & de Leon, MJ 2016, 'Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 2, pp. 49-57. https://doi.org/10.1016/j.dadm.2016.01.001

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title = "Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome",

abstract = "People with Down syndrome (DS) are at an increased risk for Alzheimer's disease (AD). After 60 years of age, >50% of DS subjects acquire dementia. Nevertheless, the age of onset is highly variable possibly because of both genetic and environmental factors. Genetics cannot be modified, but environmental risk factors present a potentially relevant intervention for DS persons at risk for AD. Among them, inflammation, important in AD of DS type, is potential target. Consistent with this hypothesis, chronic peripheral inflammation and infections may contribute to AD pathogenesis in DS. People with DS have an aggressive form of periodontitis characterized by rapid progression, significant bacterial and inflammatory burden, and an onset as early as 6 years of age. This review offers a hypothetical mechanistic link between periodontitis and AD in the DS population. Because periodontitis is a treatable condition, it may be a readily modifiable risk factor for AD.",

keywords = "Aggressive periodontal disease, Alzheimer's disease, Down syndrome, Dysbiosis, Infection, Inflammation, Neuroinflammation, Periodontal disease, Trisomy 21",

author = "Kamer, {Angela R.} and Fortea, {Juan O.} and Sebasti{\`a} Videla and Angela Mayoral and Malvin Janal and Maria Carmona-Iragui and Bessy Benejam and Craig, {Ronald G.} and Deepak Saxena and Patricia Corby and Lidia Glodzik and Annam, {Kumar Raghava Chowdary} and Miriam Robbins and {de Leon}, {Mony J.}",

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year = "2016",

doi = "10.1016/j.dadm.2016.01.001",

language = "English (US)",

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T1 - Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome

AU - Kamer, Angela R.

AU - Fortea, Juan O.

AU - Videla, Sebastià

AU - Mayoral, Angela

AU - Janal, Malvin

AU - Carmona-Iragui, Maria

AU - Benejam, Bessy

AU - Craig, Ronald G.

AU - Saxena, Deepak

AU - Corby, Patricia

AU - Glodzik, Lidia

AU - Annam, Kumar Raghava Chowdary

AU - Robbins, Miriam

AU - de Leon, Mony J.

PY - 2016

Y1 - 2016

N2 - People with Down syndrome (DS) are at an increased risk for Alzheimer's disease (AD). After 60 years of age, >50% of DS subjects acquire dementia. Nevertheless, the age of onset is highly variable possibly because of both genetic and environmental factors. Genetics cannot be modified, but environmental risk factors present a potentially relevant intervention for DS persons at risk for AD. Among them, inflammation, important in AD of DS type, is potential target. Consistent with this hypothesis, chronic peripheral inflammation and infections may contribute to AD pathogenesis in DS. People with DS have an aggressive form of periodontitis characterized by rapid progression, significant bacterial and inflammatory burden, and an onset as early as 6 years of age. This review offers a hypothetical mechanistic link between periodontitis and AD in the DS population. Because periodontitis is a treatable condition, it may be a readily modifiable risk factor for AD.

AB - People with Down syndrome (DS) are at an increased risk for Alzheimer's disease (AD). After 60 years of age, >50% of DS subjects acquire dementia. Nevertheless, the age of onset is highly variable possibly because of both genetic and environmental factors. Genetics cannot be modified, but environmental risk factors present a potentially relevant intervention for DS persons at risk for AD. Among them, inflammation, important in AD of DS type, is potential target. Consistent with this hypothesis, chronic peripheral inflammation and infections may contribute to AD pathogenesis in DS. People with DS have an aggressive form of periodontitis characterized by rapid progression, significant bacterial and inflammatory burden, and an onset as early as 6 years of age. This review offers a hypothetical mechanistic link between periodontitis and AD in the DS population. Because periodontitis is a treatable condition, it may be a readily modifiable risk factor for AD.

KW - Aggressive periodontal disease

KW - Alzheimer's disease

KW - Down syndrome

KW - Dysbiosis

KW - Infection

KW - Inflammation

KW - Neuroinflammation

KW - Periodontal disease

KW - Trisomy 21

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SN - 2352-8729

VL - 2

SP - 49

EP - 57

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

ER -

Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome

Abstract

Keywords

ASJC Scopus subject areas

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