Periodontal Inflammation in Relation to Cognitive Function in an Older Adult Danish Population

Angela R. Kamer, Douglas Morse, Poul Holm-Pedersen, Erik L. Mortensen, Kirsten Avlund

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inflammation plays a significant role in Alzheimer's disease (AD) pathogenesis. Studies have shown that systemic, peripheral infections affect AD patients. Cognitive dysfunction is a consistent finding in AD and periodontal disease is a chronic, peripheral infection often resulting in tooth loss. We hypothesized that older adults with periodontal inflammation (PI) or many missing teeth would show impaired cognition compared to subjects without PI or with few missing teeth, and among subjects with PI, those with many missing teeth would show impaired cognition compared to those with few missing teeth. The effect of PI/tooth loss on cognitive function [measured by Digit Symbol (DST) and Block Design (BDT) tests] was assessed in 70-year old Danish subjects. We found: 1) subjects with PI obtained lower mean DST scores compared to subjects without PI (p < 0.05); 2) subjects with many missing teeth had lower mean DST and BDT scores compared to subjects with few missing teeth (p < 0.05); 3) the association of PI with DST and BDT scores was dependant on the number of missing teeth (interaction: p = 0.03 and p = 0.06); and 4) education and previous cognitive scores (age 50) were important covariates. Subjects with PI had significantly lower adjusted mean DST scores compared to subjects without PI. However for adjusted BDT, the significance held only for subjects with few missing teeth. No difference in the adjusted DST and BDT scores was seen between subjects with many missing teeth compared to those with few missing teeth. These results support the hypothesis that PI may affect cognition.

Original languageEnglish (US)
Title of host publicationHandbook of Microbiome and Gut-Brain-Axis in Alzheimer�s Disease
EditorsGiulio Maria Pasinetti
PublisherIOS Press BV
Pages581-592
Number of pages12
ISBN (Electronic)9781643682884
DOIs
StatePublished - 2022

Publication series

NameAdvances in Alzheimer's Disease
Volume9
ISSN (Print)2210-5727
ISSN (Electronic)2210-5735

Keywords

  • Alzheimer's disease
  • BDT
  • DST
  • cognition
  • inflammation
  • periodontal disease
  • tooth loss

ASJC Scopus subject areas

  • Clinical Neurology

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