Peripheral cannabinoids attenuate carcinoma-induced nociception in mice

Andre V. Guerrero, Phuong Quang, Nusi Dekker, Richard C.K. Jordan, Brian L. Schmidt

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the cannabinoid receptor (CBr) agonists Win55,212-2 (non-selective) and AM1241 (CBr2 selective) and the peripheral receptor (CBr1) in carcinoma-induced pain using a mouse model. Tumors were induced in the hind paw of female mice by local injection of a human oral squamous cell carcinoma (SCC). Significant pain, as indicated by reduction in withdrawal thresholds in response to mechanical stimulation, began at 4 days after SCC inoculation and lasted to 18 days. Local administration of Win55,212-2 (10 mg/kg) and AM1241 (10 mg/kg) significantly elevated withdrawal thresholds, indicating an antinociceptive effect. Ipsilateral expression of CBr1 protein in L5 DRG was significantly upregulated compared to ipsilateral L4 DRG and in normal tissue. These findings support the suggestion that cannabinoids are capable of producing antinociception in carcinoma-induced pain.

Original languageEnglish (US)
Pages (from-to)77-81
Number of pages5
JournalNeuroscience letters
Volume433
Issue number2
DOIs
StatePublished - Mar 12 2008

Keywords

  • Cancer
  • Cancer mouse model
  • Cannabinoids
  • Oral cancer
  • Pain

ASJC Scopus subject areas

  • Neuroscience(all)

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