Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum

E. C. Azmitia, Z. T. Saccomano, M. F. Alzoobaee, M. Boldrini, P. M. Whitaker-Azmitia

Research output: Contribution to journalArticle

Abstract

In the current work, we conducted an immunocytochemical search for markers of ongoing neurogenesis (e.g. nestin) in auditory cortex from postmortem sections of autism spectrum disorder (ASD) and age-matched control donors. We found nestin labeling in cells of the vascular system, indicating blood vessels plasticity. Evidence of angiogenesis was seen throughout superior temporal cortex (primary auditory cortex), fusiform cortex (face recognition center), pons/midbrain and cerebellum in postmortem brains from ASD patients but not control brains. We found significant increases in both nestin and CD34, which are markers of angiogenesis localized to pericyte cells and endothelial cells, respectively. This labeling profile is indicative of splitting (intussusceptive), rather than sprouting, angiogenesis indicating the blood vessels are in constant flux rather than continually expanding.

Original languageEnglish (US)
Pages (from-to)1307-1318
Number of pages12
JournalJournal of Autism and Developmental Disorders
Volume46
Issue number4
DOIs
StatePublished - Apr 1 2016

Keywords

  • CD34
  • Endothelial
  • Intussusceptive
  • Nestin
  • Pericytes
  • Superior temporal cortex

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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