PERspective on PER phosphorylation

Justin Blau

doi:10.1101/gad.1696408

PERspective on PER phosphorylation

Justin Blau

Biology and Genomics

Research output: Contribution to journal › Review article › peer-review

Abstract

Period (PER) proteins are essential parts of the molecular clocks that control circadian rhythms in flies and mammals. Phosphorylation regulates PER's stability and subcellular localization; however, the physiologically relevant sites have been difficult to identify in spite of knowing the relevant kinase. In this issue of Genes & Development, Chiu and colleagues (pp. 1758-1772) identify a key phosphorylation site on PER that recruits the F-box protein Slimb to trigger PER degradation and set clock speed.

Original language	English (US)
Pages (from-to)	1737-1740
Number of pages	4
Journal	Genes and Development
Volume	22
Issue number	13
DOIs	https://doi.org/10.1101/gad.1696408
State	Published - Jul 1 2008

Keywords

CK1ε/DBT
Circadian rhythms
Drosophila
F-box protein
PER
Phosphorylation
β-TrCP/SLIMB

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.1696408

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AB - Period (PER) proteins are essential parts of the molecular clocks that control circadian rhythms in flies and mammals. Phosphorylation regulates PER's stability and subcellular localization; however, the physiologically relevant sites have been difficult to identify in spite of knowing the relevant kinase. In this issue of Genes & Development, Chiu and colleagues (pp. 1758-1772) identify a key phosphorylation site on PER that recruits the F-box protein Slimb to trigger PER degradation and set clock speed.

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KW - Phosphorylation

KW - β-TrCP/SLIMB

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PERspective on PER phosphorylation

Abstract

Keywords

ASJC Scopus subject areas

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