PERspective on PER phosphorylation

Research output: Contribution to journalReview articlepeer-review

Abstract

Period (PER) proteins are essential parts of the molecular clocks that control circadian rhythms in flies and mammals. Phosphorylation regulates PER's stability and subcellular localization; however, the physiologically relevant sites have been difficult to identify in spite of knowing the relevant kinase. In this issue of Genes & Development, Chiu and colleagues (pp. 1758-1772) identify a key phosphorylation site on PER that recruits the F-box protein Slimb to trigger PER degradation and set clock speed.

Original languageEnglish (US)
Pages (from-to)1737-1740
Number of pages4
JournalGenes and Development
Volume22
Issue number13
DOIs
StatePublished - Jul 1 2008

Keywords

  • CK1ε/DBT
  • Circadian rhythms
  • Drosophila
  • F-box protein
  • PER
  • Phosphorylation
  • β-TrCP/SLIMB

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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