Perspectives on the mitochondrial multiple conductance channel

Kathleen W. Kinnally, Timothy A. Lohret, Maria Luisa Campo, Carmen A. Mannella

    Research output: Contribution to journalShort surveypeer-review


    A multiple conductance channel (MCC) with a peak conductance of over 1 nS is recorded from mitoplasts (mitochondria with the inner membrane exposed) using patch-clamp techniques. MCC shares many general characteristics with other intracellular megachannels, many of which are weakly selective, voltage-dependent, and calcium sensitive. A role in protein import is suggested by the transient blockade of MCC by peptides responsible for targeting mitochondrial precursor proteins. MCC is compared with the peptide- sensitive channel of the outer membrane because of similarities in targeting peptide blockade. The pharmacology and regulation of MCC by physiological effectors are reviewed and compared with the properties of the pore hypothesized to be responsible for the mitochondrial inner membrane permeability transition.

    Original languageEnglish (US)
    Pages (from-to)115-123
    Number of pages9
    JournalJournal of Bioenergetics and Biomembranes
    Issue number2
    StatePublished - 1996


    • Mitochondria
    • intracellular channel
    • mitochondrial megachannel
    • multiple conductance channel
    • patch clamp
    • peptide-sensitive channel
    • permeability transition
    • protein import

    ASJC Scopus subject areas

    • Physiology
    • Cell Biology


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