PET staging of amyloidosis using striatum

Alzheimer's Disease Neuroimaging Initiative, Harvard Aging Brain Study

Research output: Contribution to journalArticle

Abstract

Introduction: Amyloid positron emission tomography (PET) data are commonly expressed as binary measures of cortical deposition. However, not all individuals with high cortical amyloid will experience rapid cognitive decline. Motivated by postmortem data, we evaluated a three-stage PET classification: low cortical; high cortical, low striatal; and high cortical, high striatal amyloid; hypothesizing this model could better reflect Alzheimer's dementia progression than a model based only on cortical measures. Methods: We classified PET data from 1433 participants (646 normal, 574 mild cognitive impairment, and 213 AD), explored the successive involvement of cortex and striatum using 3-year follow-up PET data, and evaluated the associations between PET stages, hippocampal volumes, and cognition. Results: Follow-up data indicated that PET detects amyloid first in cortex and then in striatum. Our three-category staging including striatum better predicted hippocampal volumes and subsequent cognition than a three-category staging including only cortical amyloid. Discussion: PET can evaluate amyloid expansion from cortex to subcortex. Using striatal signal as a marker of advanced amyloidosis may increase predictive power in Alzheimer's dementia research.

Original languageEnglish (US)
Pages (from-to)1281-1292
Number of pages12
JournalAlzheimer's and Dementia
Volume14
Issue number10
DOIs
StatePublished - Oct 2018

Keywords

  • Alzheimer's disease
  • Amyloid PET imaging
  • Classification
  • Cognitive aging
  • Cortex
  • MCI
  • Staging
  • Striatum
  • Structural MRI

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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    Alzheimer's Disease Neuroimaging Initiative, & Harvard Aging Brain Study (2018). PET staging of amyloidosis using striatum. Alzheimer's and Dementia, 14(10), 1281-1292. https://doi.org/10.1016/j.jalz.2018.04.011