Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum

Christian Doerig; Caroline Doerig; Paul Horrocks; Joseph Coyle; Jane Carlton; Ali Sultan; David Arnot; Richard Carter

doi:10.1016/0166-6851(95)00033-W

Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum

Christian Doerig, Caroline Doerig, Paul Horrocks, Joseph Coyle, Jane Carlton, Ali Sultan, David Arnot, Richard Carter

Research output: Contribution to journal › Article › peer-review

Abstract

A gene encoding a novel cdc2-related protein kinase has been identified in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gene family. This gene, called Pfcrk-1, is located on chromosome 4. It is most closely related to the p58^GTA gene family, members of which are negative regulators of cell growth in vertebrates. Pfcrk-1 is developmentally regulated, as indicated by stage-specific accumulation of mRNA in gametocytes.

Original language	English (US)
Pages (from-to)	167-174
Number of pages	8
Journal	Molecular and Biochemical Parasitology
Volume	70
Issue number	1-2
DOIs	https://doi.org/10.1016/0166-6851(95)00033-W
State	Published - Mar 1995

Keywords

Cell-cycle control
Plasmodium falciparum
Protein kinase
Sexual differentiation
p58

ASJC Scopus subject areas

Parasitology
Molecular Biology

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10.1016/0166-6851(95)00033-W

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title = "Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum",

abstract = "A gene encoding a novel cdc2-related protein kinase has been identified in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gene family. This gene, called Pfcrk-1, is located on chromosome 4. It is most closely related to the p58GTA gene family, members of which are negative regulators of cell growth in vertebrates. Pfcrk-1 is developmentally regulated, as indicated by stage-specific accumulation of mRNA in gametocytes.",

keywords = "Cell-cycle control, Plasmodium falciparum, Protein kinase, Sexual differentiation, p58",

author = "Christian Doerig and Caroline Doerig and Paul Horrocks and Joseph Coyle and Jane Carlton and Ali Sultan and David Arnot and Richard Carter",

year = "1995",

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language = "English (US)",

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T1 - Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum

AU - Doerig, Christian

AU - Doerig, Caroline

AU - Horrocks, Paul

AU - Coyle, Joseph

AU - Carlton, Jane

AU - Sultan, Ali

AU - Arnot, David

AU - Carter, Richard

PY - 1995/3

Y1 - 1995/3

N2 - A gene encoding a novel cdc2-related protein kinase has been identified in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gene family. This gene, called Pfcrk-1, is located on chromosome 4. It is most closely related to the p58GTA gene family, members of which are negative regulators of cell growth in vertebrates. Pfcrk-1 is developmentally regulated, as indicated by stage-specific accumulation of mRNA in gametocytes.

AB - A gene encoding a novel cdc2-related protein kinase has been identified in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gene family. This gene, called Pfcrk-1, is located on chromosome 4. It is most closely related to the p58GTA gene family, members of which are negative regulators of cell growth in vertebrates. Pfcrk-1 is developmentally regulated, as indicated by stage-specific accumulation of mRNA in gametocytes.

KW - Cell-cycle control

KW - Plasmodium falciparum

KW - Protein kinase

KW - Sexual differentiation

KW - p58

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AN - SCOPUS:0028988027

SN - 0166-6851

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EP - 174

JO - Molecular and Biochemical Parasitology

JF - Molecular and Biochemical Parasitology

IS - 1-2

ER -

Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum

Abstract

Keywords

ASJC Scopus subject areas

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