TY - JOUR
T1 - Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum
AU - Doerig, Christian
AU - Doerig, Caroline
AU - Horrocks, Paul
AU - Coyle, Joseph
AU - Carlton, Jane
AU - Sultan, Ali
AU - Arnot, David
AU - Carter, Richard
PY - 1995/3
Y1 - 1995/3
N2 - A gene encoding a novel cdc2-related protein kinase has been identified in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gene family. This gene, called Pfcrk-1, is located on chromosome 4. It is most closely related to the p58GTA gene family, members of which are negative regulators of cell growth in vertebrates. Pfcrk-1 is developmentally regulated, as indicated by stage-specific accumulation of mRNA in gametocytes.
AB - A gene encoding a novel cdc2-related protein kinase has been identified in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gene family. This gene, called Pfcrk-1, is located on chromosome 4. It is most closely related to the p58GTA gene family, members of which are negative regulators of cell growth in vertebrates. Pfcrk-1 is developmentally regulated, as indicated by stage-specific accumulation of mRNA in gametocytes.
KW - Cell-cycle control
KW - Plasmodium falciparum
KW - Protein kinase
KW - Sexual differentiation
KW - p58
UR - http://www.scopus.com/inward/record.url?scp=0028988027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028988027&partnerID=8YFLogxK
U2 - 10.1016/0166-6851(95)00033-W
DO - 10.1016/0166-6851(95)00033-W
M3 - Article
C2 - 7637697
AN - SCOPUS:0028988027
VL - 70
SP - 167
EP - 174
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
SN - 0166-6851
IS - 1-2
ER -